Human Gene CXCR1 (ENST00000295683.3_7) from GENCODE V47lift37
  Description: C-X-C motif chemokine receptor 1 (from RefSeq NM_000634.3)
Gencode Transcript: ENST00000295683.3_7
Gencode Gene: ENSG00000163464.8_9
Transcript (Including UTRs)
   Position: hg19 chr2:219,027,564-219,031,685 Size: 4,122 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr2:219,028,882-219,029,934 Size: 1,053 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:219,027,564-219,031,685)mRNA (may differ from genome)Protein (350 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CXCR1_HUMAN
DESCRIPTION: RecName: Full=C-X-C chemokine receptor type 1; Short=CXC-R1; Short=CXCR-1; AltName: Full=CDw128a; AltName: Full=High affinity interleukin-8 receptor A; Short=IL-8R A; AltName: Full=IL-8 receptor type 1; AltName: CD_antigen=CD181;
FUNCTION: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=Wikipedia; Note=CXC chemokine receptors entry; URL="http://en.wikipedia.org/wiki/CXC_chemokine_receptors";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il8ra/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CXCR1
Diseases sorted by gene-association score: hiv-1* (169), acute pyelonephritis (22), idiopathic anterior uveitis (13), bacteriuria (11), pyelonephritis (11), chronic nk-cell lymphocytosis (8), denture stomatitis (8), idiopathic bronchiectasis (7), cervix small cell carcinoma (6), pyelitis (5), hemoglobin c disease (5), cystic fibrosis (2), pulmonary fibrosis, idiopathic (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 421.25 RPKM in Whole Blood
Total median expression: 465.07 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.4088-0.220 Picture PostScript Text
3' UTR -467.101318-0.354 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR000174 - Chemokine_CXC/IL8_rcpt
IPR001355 - Chemokine_CXCR1/IL8RA
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1ILP - NMR MuPIT 1ILQ - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P25024
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
  Ensembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004918 interleukin-8 receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0016494 C-X-C chemokine receptor activity
GO:0019959 interleukin-8 binding

Biological Process:
GO:0002407 dendritic cell chemotaxis
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0031623 receptor internalization
GO:0038112 interleukin-8-mediated signaling pathway
GO:0043312 neutrophil degranulation
GO:0070098 chemokine-mediated signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030667 secretory granule membrane


-  Descriptions from all associated GenBank mRNAs
  LQ882926 - Sequence 75 from Patent WO2018160841.
AK309632 - Homo sapiens cDNA, FLJ99673.
JD080534 - Sequence 61558 from Patent EP1572962.
JD261584 - Sequence 242608 from Patent EP1572962.
JD086922 - Sequence 67946 from Patent EP1572962.
JD206170 - Sequence 187194 from Patent EP1572962.
JD049078 - Sequence 30102 from Patent EP1572962.
JD344956 - Sequence 325980 from Patent EP1572962.
JD151299 - Sequence 132323 from Patent EP1572962.
JD393460 - Sequence 374484 from Patent EP1572962.
JD527210 - Sequence 508234 from Patent EP1572962.
JD410860 - Sequence 391884 from Patent EP1572962.
L19591 - Homo sapiens interleukin 8 receptor alpha (IL8RA) mRNA, complete cds.
BC072397 - Homo sapiens interleukin 8 receptor, alpha, mRNA (cDNA clone MGC:87714 IMAGE:5755928), complete cds.
BC028221 - Homo sapiens interleukin 8 receptor, alpha, mRNA (cDNA clone MGC:40015 IMAGE:5217529), complete cds.
M68932 - Human IL-8 receptor mRNA, complete cds.
JD119809 - Sequence 100833 from Patent EP1572962.
JD506827 - Sequence 487851 from Patent EP1572962.
JD402312 - Sequence 383336 from Patent EP1572962.
JD041587 - Sequence 22611 from Patent EP1572962.
JD485887 - Sequence 466911 from Patent EP1572962.
JD380809 - Sequence 361833 from Patent EP1572962.
JD189274 - Sequence 170298 from Patent EP1572962.
JD284697 - Sequence 265721 from Patent EP1572962.
JD352802 - Sequence 333826 from Patent EP1572962.
AK298647 - Homo sapiens cDNA FLJ51527 complete cds, moderately similar to High affinity interleukin-8 receptor A.
JD253814 - Sequence 234838 from Patent EP1572962.
JD409826 - Sequence 390850 from Patent EP1572962.
JD060869 - Sequence 41893 from Patent EP1572962.
JD241475 - Sequence 222499 from Patent EP1572962.
JD074039 - Sequence 55063 from Patent EP1572962.
JD044175 - Sequence 25199 from Patent EP1572962.
JD386114 - Sequence 367138 from Patent EP1572962.
CR541994 - Homo sapiens full open reading frame cDNA clone RZPDo834D0835D for gene IL8RA, interleukin 8 receptor, alpha; complete cds, incl. stopcodon.
E11244 - Human cDNA encoding interleukin 8 receptor type A.
AK312668 - Homo sapiens cDNA, FLJ93060, Homo sapiens interleukin 8 receptor, alpha (IL8RA), mRNA.
KJ897048 - Synthetic construct Homo sapiens clone ccsbBroadEn_06442 CXCR1 gene, encodes complete protein.
DQ891718 - Synthetic construct clone IMAGE:100004348; FLH179380.01X; RZPDo839F10130D interleukin 8 receptor, alpha (IL8RA) gene, encodes complete protein.
DQ894895 - Synthetic construct Homo sapiens clone IMAGE:100009355; FLH179376.01L; RZPDo839F10129D interleukin 8 receptor, alpha (IL8RA) gene, encodes complete protein.
CR542029 - Homo sapiens full open reading frame cDNA clone RZPDo834E0935D for gene IL8RA, interleukin 8 receptor, alpha; complete cds, without stopcodon.
AB464598 - Synthetic construct DNA, clone: pF1KB9835, Homo sapiens IL8RA gene for interleukin 8 receptor, alpha, without stop codon, in Flexi system.
U11871 - Human interleukin-8 receptor type A (IL8RA) mRNA, partial cds.
MP584576 - Sequence 75 from Patent WO2020081767.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P25024 (Reactome details) participates in the following event(s):

R-HSA-373791 Receptor CXCR1 binds CXCL6 and CXCL8 ligands
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-6798743 Exocytosis of secretory granule membrane proteins
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-168249 Innate Immune System
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-168256 Immune System
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2R6Q3, CMKAR1, CXCR1_HUMAN, ENST00000295683.1, ENST00000295683.2, IL8RA, NM_000634, P25024, Q2YEF8, Q2YEG4, Q2YEG5, Q2YEG7, Q2YEG8, Q53R18, Q6IN95, Q8N6T6, Q9P2T8, Q9P2T9, Q9P2U0, Q9P2U1, Q9P2U2, uc317lna.1, uc317lna.2
UCSC ID: ENST00000295683.3_7
RefSeq Accession: NM_000634.3
Protein: P25024 (aka CXCR1_HUMAN or IL8A_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.