Human Gene CSH1 (ENST00000316193.13_7) from GENCODE V47lift37

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Description: chorionic somatomammotropin hormone 1 (from RefSeq NM_001317.6)
Gencode Transcript: ENST00000316193.13_7
Gencode Gene: ENSG00000136488.15_9
Transcript (Including UTRs)
Position: hg19 chr17:61,972,278-61,973,934 Size: 1,657 Total Exon Count: 5 Strand: -
Coding Region
Position: hg19 chr17:61,972,382-61,973,871 Size: 1,490 Coding Exon Count: 5

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names
Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:61,972,278-61,973,934)			mRNA (may differ from genome)		Protein (217 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: CSH1 Diseases sorted by gene-association score: choriocarcinoma (25), persistent fetal circulation syndrome (16), testicular trophoblastic tumor (16), non-gestational choriocarcinoma (15), juvenile type testicular granulosa cell tumor (15), testicular granulosa cell tumor (15), silver-russell syndrome (11), trophoblastic neoplasm (9), gestational choriocarcinoma (9), choriocarcinoma of the testis (9), epithelioid trophoblastic tumor (8), gestational trophoblastic neoplasm (8), rh isoimmunization (8), placental site trophoblastic tumor (7), germ cell and embryonal cancer (7), chronic salpingitis (6), blood group incompatibility (6), choriocarcinoma of ovary (6), uterine disease (5), placenta disease (5), breast metaplastic carcinoma (5), female reproductive system disease (1), noonan syndrome 1 (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C009505 4,4'-diaminodiphenylmethane D004967 Estrogens D000431 Ethanol D004397 Fonofos D006861 Hydrogen Peroxide D010278 Parathion D011374 Progesterone C016601 afimoxifene C006632 arsenic trioxide C014347 decitabine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 0.36 RPKM in Pituitary Total median expression: 0.46 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-14.50	63	-0.230	Picture	PostScript	Text
3' UTR	-20.10	104	-0.193	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	BC005921 - Homo sapiens chorionic somatomammotropin hormone 1 (placental lactogen), mRNA (cDNA clone MGC:14518 IMAGE:4043768), complete cds. J00118 - Human placental lactogen hormone (PL-4) mRNA, complete cds. BC057768 - Homo sapiens chorionic somatomammotropin hormone 1 (placental lactogen), mRNA (cDNA clone MGC:71529 IMAGE:30337725), complete cds. BC020756 - Homo sapiens chorionic somatomammotropin hormone 1 (placental lactogen), mRNA (cDNA clone MGC:22607 IMAGE:4769769), complete cds. BC002717 - Homo sapiens chorionic somatomammotropin hormone 1 (placental lactogen), mRNA (cDNA clone MGC:3714 IMAGE:3631916), complete cds. BC062775 - Homo sapiens chorionic somatomammotropin hormone 1 (placental lactogen), mRNA (cDNA clone MGC:72182 IMAGE:4604848), complete cds. AK291587 - Homo sapiens cDNA FLJ75407 complete cds, highly similar to Homo sapiens chorionic somatomammotropin hormone 1 (placental lactogen) (CSH1), transcript variant 1, mRNA. JD081364 - Sequence 62388 from Patent EP1572962. JD124037 - Sequence 105061 from Patent EP1572962. M25118 - Human chorionic somatomammotropin (HCS) mRNA, 3' end. V00593 - Human gene for somatomammotropin (hormone). KJ905720 - Synthetic construct Homo sapiens clone ccsbBroadEn_15390 CSH1 gene, encodes complete protein. BT006926 - Homo sapiens chorionic somatomammotropin hormone 1 (placental lactogen) mRNA, complete cds. CU675185 - Synthetic construct Homo sapiens gateway clone IMAGE:100018035 5' read CSH1 mRNA. CU691218 - Synthetic construct Homo sapiens gateway clone IMAGE:100020818 5' read CSH1 mRNA. HQ447195 - Synthetic construct Homo sapiens clone IMAGE:100070489; CCSB005769_01 chorionic somatomammotropin hormone 1 (placental lactogen) (CSH1) gene, encodes complete protein. KJ890979 - Synthetic construct Homo sapiens clone ccsbBroadEn_00373 CSH1 gene, encodes complete protein. KJ896657 - Synthetic construct Homo sapiens clone ccsbBroadEn_06051 CSH1 gene, encodes complete protein. AB528578 - Synthetic construct DNA, clone: pF1KB6998, Homo sapiens CSH1 gene for chorionic somatomammotropin hormone 1, without stop codon, in Flexi system. CU678142 - Synthetic construct Homo sapiens gateway clone IMAGE:100018593 5' read CSH1 mRNA. JD537850 - Sequence 518874 from Patent EP1572962. JD139944 - Sequence 120968 from Patent EP1572962. JD096841 - Sequence 77865 from Patent EP1572962. JD139706 - Sequence 120730 from Patent EP1572962. JD522696 - Sequence 503720 from Patent EP1572962. JD186554 - Sequence 167578 from Patent EP1572962. JD131309 - Sequence 112333 from Patent EP1572962. JD521211 - Sequence 502235 from Patent EP1572962. JD438144 - Sequence 419168 from Patent EP1572962. JD049395 - Sequence 30419 from Patent EP1572962. M35419 - Homo sapiens variant chorionic somatomammotropin-1 (hCS) mRNA, 5' region. JD324980 - Sequence 306004 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: CSH1_HUMAN, ENST00000316193.1, ENST00000316193.10, ENST00000316193.11, ENST00000316193.12, ENST00000316193.2, ENST00000316193.3, ENST00000316193.4, ENST00000316193.5, ENST00000316193.6, ENST00000316193.7, ENST00000316193.8, ENST00000316193.9, NM_001317, P01243, P0DML2, Q0VDB1, Q14407, uc317pyw.1, uc317pyw.2 UCSC ID: ENST00000316193.13_7 RefSeq Accession: NM_001317.6

Gene Model Information


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Methods, Credits, and Use Restrictions


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