Human Gene CRIP3 (ENST00000274990.4_5) from GENCODE V47lift37
  Description: Q6Q6R5-3; Q13643: FHL3; NbExp=3; IntAct=EBI-12925520, EBI-741101; Q6Q6R5-3; O60568: PLOD3; NbExp=3; IntAct=EBI-12925520, EBI-741582; (from UniProt Q6Q6R5)
Gencode Transcript: ENST00000274990.4_5
Gencode Gene: ENSG00000146215.14_11
Transcript (Including UTRs)
   Position: hg19 chr6:43,273,563-43,276,535 Size: 2,973 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr6:43,273,704-43,276,530 Size: 2,827 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:43,273,563-43,276,535)mRNA (may differ from genome)Protein (217 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CRIP3_HUMAN
DESCRIPTION: RecName: Full=Cysteine-rich protein 3; Short=CRP-3; AltName: Full=Chromosome 6 LIM domain only protein; Short=h6LIMo;
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Expressed in most tissues, but not in skeletal muscle.
SIMILARITY: Contains 2 LIM zinc-binding domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.84 RPKM in Testis
Total median expression: 112.53 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -44.40141-0.315 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001781 - Znf_LIM

Pfam Domains:
PF00412 - LIM domain

SCOP Domains:
48695 - Multiheme cytochromes
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57903 - FYVE/PHD zinc finger
161229 - E6 C-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q6Q6R5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046872 metal ion binding

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AY555741 - Homo sapiens LIM-only isoform A mRNA, complete cds.
BC146404 - Synthetic construct Homo sapiens clone IMAGE:100015148, MGC:180223 cysteine-rich protein 3 (CRIP3) mRNA, encodes complete protein.
BC148846 - Synthetic construct Homo sapiens clone IMAGE:100015861, MGC:183198 cysteine-rich protein 3 (CRIP3) mRNA, encodes complete protein.
AB463553 - Synthetic construct DNA, clone: pF1KB7394, Homo sapiens CRIP3 gene for cysteine-rich protein 3, without stop codon, in Flexi system.
AY555743 - Homo sapiens LIM-only isoform C mRNA, complete cds.
AY555742 - Homo sapiens LIM-only isoform B mRNA, complete cds.
AY555744 - Homo sapiens LIM-only isoform D mRNA, complete cds.
AK124657 - Homo sapiens cDNA FLJ42666 fis, clone BRAMY2020050.
BC068247 - Homo sapiens cDNA clone IMAGE:4825361.

-  Other Names for This Gene
  Alternate Gene Symbols: A2A436, AY555743, CRIP3_HUMAN, CRP3, ENST00000274990.1, ENST00000274990.2, ENST00000274990.3, Q5T043, Q6Q6R4, Q6Q6R5, Q6Q6R6, Q6Q6R7, uc317jgy.1, uc317jgy.2
UCSC ID: ENST00000274990.4_5
RefSeq Accession: NM_206922.3
Protein: Q6Q6R5 (aka CRIP3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.