ID:CRUM3_HUMAN DESCRIPTION: RecName: Full=Protein crumbs homolog 3; Flags: Precursor; FUNCTION: Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. SUBUNIT: Interacts with MPP5, PARD6A and INADL. SUBCELLULAR LOCATION: Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells. TISSUE SPECIFICITY: Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate. DOMAIN: The PDZ-binding motif is involved in the interactions with PARD6A and MPP5.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q9BUF7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AY103469 - Homo sapiens crumbs 3 mRNA, complete cds. AK292956 - Homo sapiens cDNA FLJ76581 complete cds, highly similar to Homo sapiens crumbs homolog 3 (Drosophila) (CRB3), transcript variant 2, mRNA. AF503290 - Homo sapiens unknown protein mRNA, complete cds. AY358684 - Homo sapiens clone DNA60625 CRB3 (UNQ588) mRNA, complete cds. BC018409 - Homo sapiens crumbs homolog 3 (Drosophila), mRNA (cDNA clone MGC:17303 IMAGE:3861124), complete cds. JD343262 - Sequence 324286 from Patent EP1572962. AK000653 - Homo sapiens cDNA FLJ20646 fis, clone KAT02157. BC002652 - Homo sapiens crumbs homolog 3 (Drosophila), mRNA (cDNA clone MGC:4280 IMAGE:3610257), complete cds. KJ895183 - Synthetic construct Homo sapiens clone ccsbBroadEn_04577 CRB3 gene, encodes complete protein. KJ899945 - Synthetic construct Homo sapiens clone ccsbBroadEn_09339 CRB3 gene, encodes complete protein. JD260207 - Sequence 241231 from Patent EP1572962. JD140956 - Sequence 121980 from Patent EP1572962. JD477379 - Sequence 458403 from Patent EP1572962. JD269452 - Sequence 250476 from Patent EP1572962. JD364795 - Sequence 345819 from Patent EP1572962. JD392138 - Sequence 373162 from Patent EP1572962. JD054139 - Sequence 35163 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BUF7 (Reactome details) participates in the following event(s):
R-HSA-420661 Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions R-HSA-420029 Tight junction interactions R-HSA-421270 Cell-cell junction organization R-HSA-446728 Cell junction organization R-HSA-1500931 Cell-Cell communication
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
