ID:COPZ2_HUMAN DESCRIPTION: RecName: Full=Coatomer subunit zeta-2; AltName: Full=Zeta-2-coat protein; Short=Zeta-2 COP; FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity). SUBUNIT: Oligomeric complex. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). SIMILARITY: Belongs to the adaptor complexes small subunit family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P299
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0006886 intracellular protein transport GO:0006888 ER to Golgi vesicle-mediated transport GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0015031 protein transport GO:0016192 vesicle-mediated transport
LF209293 - JP 2014500723-A/16796: Polycomb-Associated Non-Coding RNAs. JD192202 - Sequence 173226 from Patent EP1572962. AB037938 - Homo sapiens COPZ2 mRNA for nonclathrin coat protein zeta-COP, complete cds. AB047849 - Homo sapiens mRNA for zeta2-COP, complete cds. BC015924 - Homo sapiens coatomer protein complex, subunit zeta 2, mRNA (cDNA clone MGC:23008 IMAGE:4850757), complete cds. JD555857 - Sequence 536881 from Patent EP1572962. JD490338 - Sequence 471362 from Patent EP1572962. LF327497 - JP 2014500723-A/135000: Polycomb-Associated Non-Coding RNAs. JD108864 - Sequence 89888 from Patent EP1572962. JD045912 - Sequence 26936 from Patent EP1572962. JD520934 - Sequence 501958 from Patent EP1572962. JD325112 - Sequence 306136 from Patent EP1572962. JD252253 - Sequence 233277 from Patent EP1572962. JD252252 - Sequence 233276 from Patent EP1572962. JD332100 - Sequence 313124 from Patent EP1572962. JD308847 - Sequence 289871 from Patent EP1572962. JD252923 - Sequence 233947 from Patent EP1572962. LF327496 - JP 2014500723-A/134999: Polycomb-Associated Non-Coding RNAs. JD464501 - Sequence 445525 from Patent EP1572962. JD048696 - Sequence 29720 from Patent EP1572962. JD553558 - Sequence 534582 from Patent EP1572962. DQ893053 - Synthetic construct clone IMAGE:100005683; FLH193088.01X; RZPDo839C1078D coatomer protein complex, subunit zeta 2 (COPZ2) gene, encodes complete protein. DQ896301 - Synthetic construct Homo sapiens clone IMAGE:100010761; FLH193084.01L; RZPDo839C1068D coatomer protein complex, subunit zeta 2 (COPZ2) gene, encodes complete protein. AB590254 - Synthetic construct DNA, clone: pFN21AB6937, Homo sapiens COPZ2 gene for coatomer protein complex, subunit zeta 2, without stop codon, in Flexi system. LF327494 - JP 2014500723-A/134997: Polycomb-Associated Non-Coding RNAs. LF327492 - JP 2014500723-A/134995: Polycomb-Associated Non-Coding RNAs. MA563074 - JP 2018138019-A/135000: Polycomb-Associated Non-Coding RNAs. MA563073 - JP 2018138019-A/134999: Polycomb-Associated Non-Coding RNAs. MA563071 - JP 2018138019-A/134997: Polycomb-Associated Non-Coding RNAs. MA563069 - JP 2018138019-A/134995: Polycomb-Associated Non-Coding RNAs. MA444870 - JP 2018138019-A/16796: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9P299 (Reactome details) participates in the following event(s):
R-HSA-6807872 Active ARF recruits coatomer R-HSA-6811412 Active ARF recruits coatomer to the Golgi R-HSA-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex R-HSA-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-6807877 ARFGAPs stimulate ARF GTPase activity R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
