ID:COPZ1_HUMAN DESCRIPTION: RecName: Full=Coatomer subunit zeta-1; AltName: Full=Zeta-1-coat protein; Short=Zeta-1 COP; FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). FUNCTION: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. SUBUNIT: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the adaptor complexes small subunit family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P61923
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0006886 intracellular protein transport GO:0006888 ER to Golgi vesicle-mediated transport GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0006891 intra-Golgi vesicle-mediated transport GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:1901998 toxin transport
AF151878 - Homo sapiens CGI-120 protein mRNA, complete cds. AK311027 - Homo sapiens cDNA, FLJ18069. AF161529 - Homo sapiens HSPC181 mRNA, complete cds. AK025956 - Homo sapiens cDNA: FLJ22303 fis, clone HRC04902, highly similar to AF151878 Homo sapiens CGI-120 protein mRNA. AK026190 - Homo sapiens cDNA: FLJ22537 fis, clone HRC13178, highly similar to AF151878 Homo sapiens CGI-120 protein mRNA. AK293377 - Homo sapiens cDNA FLJ59844 complete cds, highly similar to Coatomer subunit zeta-1. AK295325 - Homo sapiens cDNA FLJ59891 complete cds, moderately similar to Coatomer subunit zeta-1. AB047848 - Homo sapiens mRNA for zeta1-COP, complete cds. AF086911 - Homo sapiens z-cop mRNA, complete cds. AK223188 - Homo sapiens mRNA for coatomer protein complex, subunit zeta 1 variant, clone: REC05816. BC002849 - Homo sapiens coatomer protein complex, subunit zeta 1, mRNA (cDNA clone MGC:3349 IMAGE:3637869), complete cds. CU678240 - Synthetic construct Homo sapiens gateway clone IMAGE:100020172 5' read COPZ1 mRNA. AB463530 - Synthetic construct DNA, clone: pF1KB8106, Homo sapiens COPZ1 gene for coatomer protein complex, subunit zeta 1, without stop codon, in Flexi system. HQ448364 - Synthetic construct Homo sapiens clone IMAGE:100071788; CCSB004196_02 coatomer protein complex, subunit zeta 1 (COPZ1) gene, encodes complete protein. KJ893292 - Synthetic construct Homo sapiens clone ccsbBroadEn_02686 COPZ1 gene, encodes complete protein. JD554700 - Sequence 535724 from Patent EP1572962. JD299902 - Sequence 280926 from Patent EP1572962. JD431535 - Sequence 412559 from Patent EP1572962. JD093461 - Sequence 74485 from Patent EP1572962. JD508568 - Sequence 489592 from Patent EP1572962. JD282381 - Sequence 263405 from Patent EP1572962. JD398167 - Sequence 379191 from Patent EP1572962. JD085772 - Sequence 66796 from Patent EP1572962. JD556070 - Sequence 537094 from Patent EP1572962. JD402826 - Sequence 383850 from Patent EP1572962. JD157607 - Sequence 138631 from Patent EP1572962. JD214669 - Sequence 195693 from Patent EP1572962. JD139284 - Sequence 120308 from Patent EP1572962. JD428921 - Sequence 409945 from Patent EP1572962. JD334935 - Sequence 315959 from Patent EP1572962. JD412113 - Sequence 393137 from Patent EP1572962. JD493884 - Sequence 474908 from Patent EP1572962. JD260748 - Sequence 241772 from Patent EP1572962. JD536049 - Sequence 517073 from Patent EP1572962. JD155475 - Sequence 136499 from Patent EP1572962. JD459890 - Sequence 440914 from Patent EP1572962. JD120928 - Sequence 101952 from Patent EP1572962. JD465226 - Sequence 446250 from Patent EP1572962. JD394170 - Sequence 375194 from Patent EP1572962. JD188298 - Sequence 169322 from Patent EP1572962. JD455808 - Sequence 436832 from Patent EP1572962. JD348336 - Sequence 329360 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P61923 (Reactome details) participates in the following event(s):
R-HSA-6807872 Active ARF recruits coatomer R-HSA-6811412 Active ARF recruits coatomer to the Golgi R-HSA-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex R-HSA-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-6807877 ARFGAPs stimulate ARF GTPase activity R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
