Human Gene CNNM3 (ENST00000305510.4_4) from GENCODE V47lift37
  Description: cyclin and CBS domain divalent metal cation transport mediator 3, transcript variant 1 (from RefSeq NM_017623.5)
Gencode Transcript: ENST00000305510.4_4
Gencode Gene: ENSG00000168763.16_7
Transcript (Including UTRs)
   Position: hg19 chr2:97,482,005-97,501,119 Size: 19,115 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr2:97,482,015-97,498,353 Size: 16,339 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:97,482,005-97,501,119)mRNA (may differ from genome)Protein (707 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CNNM3_HUMAN
DESCRIPTION: RecName: Full=Metal transporter CNNM3; AltName: Full=Ancient conserved domain-containing protein 3; AltName: Full=Cyclin-M3;
FUNCTION: Probable metal transporter (By similarity).
INTERACTION: Q99750:MDFI; NbExp=3; IntAct=EBI-741032, EBI-724076;
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in heart and spleen.
MISCELLANEOUS: Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo.
SIMILARITY: Belongs to the ACDP family.
SIMILARITY: Contains 2 CBS domains.
SIMILARITY: Contains 1 DUF21 domain.
SEQUENCE CAUTION: Sequence=AAF86377.1; Type=Erroneous initiation; Sequence=AAH07199.3; Type=Erroneous initiation; Sequence=BAA90891.1; Type=Frameshift; Positions=315;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.63 RPKM in Brain - Cerebellum
Total median expression: 279.15 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -883.492766-0.319 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000644 - Cysta_beta_synth_core
IPR002550 - DUF21

Pfam Domains:
PF00571 - CBS domain

SCOP Domains:
51206 - cAMP-binding domain-like
54631 - CBS-domain pair

ModBase Predicted Comparative 3D Structure on Q8NE01
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006811 ion transport

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF205180 - JP 2014500723-A/12683: Polycomb-Associated Non-Coding RNAs.
BC037272 - Homo sapiens cyclin M3, mRNA (cDNA clone MGC:27075 IMAGE:4823510), complete cds.
AK126847 - Homo sapiens cDNA FLJ44899 fis, clone BRAMY3002886, highly similar to Homo sapiens cyclin M3 (CNNM3), transcript variant 1, mRNA.
LF317340 - JP 2014500723-A/124843: Polycomb-Associated Non-Coding RNAs.
BC007199 - Homo sapiens cyclin M3, mRNA (cDNA clone MGC:12617 IMAGE:2964706), complete cds.
AF216965 - Homo sapiens ancient conserved domain protein 3 (ACDP3) mRNA, complete cds.
AK000025 - Homo sapiens cDNA FLJ20018 fis, clone ADSE00909.
CU675553 - Synthetic construct Homo sapiens gateway clone IMAGE:100019066 5' read CNNM3 mRNA.
KJ906114 - Synthetic construct Homo sapiens clone ccsbBroadEn_15784 CNNM3 gene, encodes complete protein.
BC018604 - Homo sapiens cyclin M3, mRNA (cDNA clone IMAGE:3919228).
CR749702 - Homo sapiens mRNA; cDNA DKFZp434I1016 (from clone DKFZp434I1016).
BC022944 - Homo sapiens, clone IMAGE:4346647, mRNA, partial cds.
LF317342 - JP 2014500723-A/124845: Polycomb-Associated Non-Coding RNAs.
AK128698 - Homo sapiens cDNA FLJ46865 fis, clone UTERU3011795.
JD240401 - Sequence 221425 from Patent EP1572962.
JD323838 - Sequence 304862 from Patent EP1572962.
JD471004 - Sequence 452028 from Patent EP1572962.
JD270909 - Sequence 251933 from Patent EP1572962.
JD191912 - Sequence 172936 from Patent EP1572962.
JD339538 - Sequence 320562 from Patent EP1572962.
JD098292 - Sequence 79316 from Patent EP1572962.
JD124851 - Sequence 105875 from Patent EP1572962.
JD074092 - Sequence 55116 from Patent EP1572962.
JD469562 - Sequence 450586 from Patent EP1572962.
JD051745 - Sequence 32769 from Patent EP1572962.
JD462461 - Sequence 443485 from Patent EP1572962.
JD278477 - Sequence 259501 from Patent EP1572962.
JD454241 - Sequence 435265 from Patent EP1572962.
JD380215 - Sequence 361239 from Patent EP1572962.
JD544454 - Sequence 525478 from Patent EP1572962.
JD112973 - Sequence 93997 from Patent EP1572962.
JD195647 - Sequence 176671 from Patent EP1572962.
JD280654 - Sequence 261678 from Patent EP1572962.
JD476505 - Sequence 457529 from Patent EP1572962.
JD436441 - Sequence 417465 from Patent EP1572962.
LF317345 - JP 2014500723-A/124848: Polycomb-Associated Non-Coding RNAs.
LF317346 - JP 2014500723-A/124849: Polycomb-Associated Non-Coding RNAs.
LF317347 - JP 2014500723-A/124850: Polycomb-Associated Non-Coding RNAs.
JD293388 - Sequence 274412 from Patent EP1572962.
JD523061 - Sequence 504085 from Patent EP1572962.
MA440757 - JP 2018138019-A/12683: Polycomb-Associated Non-Coding RNAs.
MA552917 - JP 2018138019-A/124843: Polycomb-Associated Non-Coding RNAs.
MA552919 - JP 2018138019-A/124845: Polycomb-Associated Non-Coding RNAs.
MA552922 - JP 2018138019-A/124848: Polycomb-Associated Non-Coding RNAs.
MA552923 - JP 2018138019-A/124849: Polycomb-Associated Non-Coding RNAs.
MA552924 - JP 2018138019-A/124850: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ACDP3, B3KX67, CNNM3_HUMAN, ENST00000305510.1, ENST00000305510.2, ENST00000305510.3, NM_017623, Q8NE01, Q8TBV4, Q96IW4, Q9NRK4, Q9NXW6, uc317nqj.1, uc317nqj.2
UCSC ID: ENST00000305510.4_4
RefSeq Accession: NM_017623.5
Protein: Q8NE01 (aka CNNM3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.