Human Gene CMPK1 (ENST00000371873.10_3) from GENCODE V47lift37
  Description: cytidine/uridine monophosphate kinase 1, transcript variant 1 (from RefSeq NM_016308.3)
Gencode Transcript: ENST00000371873.10_3
Gencode Gene: ENSG00000162368.15_8
Transcript (Including UTRs)
   Position: hg19 chr1:47,799,462-47,844,511 Size: 45,050 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr1:47,799,618-47,842,417 Size: 42,800 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:47,799,462-47,844,511)mRNA (may differ from genome)Protein (228 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KCY_HUMAN
DESCRIPTION: RecName: Full=UMP-CMP kinase; EC=2.7.4.14; AltName: Full=Cytidine monophosphate kinase; AltName: Full=Cytidylate kinase; AltName: Full=Deoxycytidylate kinase; AltName: Full=Uridine monophosphate kinase; AltName: Full=Uridine monophosphate/cytidine monophosphate kinase; Short=UMP/CMP kinase; Short=UMP/CMPK;
FUNCTION: Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.
CATALYTIC ACTIVITY: ATP + (d)CMP = ADP + (d)CDP.
CATALYTIC ACTIVITY: ATP + UMP = ADP + UDP.
COFACTOR: Magnesium.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Mainly nuclear.
TISSUE SPECIFICITY: Ubiquitously expressed.
SIMILARITY: Belongs to the adenylate kinase family.
SEQUENCE CAUTION: Sequence=AAF17709.1; Type=Erroneous initiation; Sequence=AAH14961.1; Type=Erroneous initiation; Sequence=BAD96734.1; Type=Erroneous initiation; Sequence=CAI13471.1; Type=Erroneous gene model prediction; Sequence=CAI14972.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CMPK1
Diseases sorted by gene-association score: duodenitis (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 56.98 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1764.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -89.90156-0.576 Picture PostScript Text
3' UTR -474.702094-0.227 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000850 - Adenylate_kin
IPR006266 - UMP_CMP_kinase

Pfam Domains:
PF00406 - Adenylate kinase
PF02223 - Thymidylate kinase
PF06414 - Zeta toxin
PF13207 - AAA domain
PF13238 - AAA domain

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1TEV - X-ray


ModBase Predicted Comparative 3D Structure on P30085
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004127 cytidylate kinase activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0004849 uridine kinase activity
GO:0005524 ATP binding
GO:0009041 uridylate kinase activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019205 nucleobase-containing compound kinase activity
GO:0050145 nucleoside phosphate kinase activity

Biological Process:
GO:0006139 nucleobase-containing compound metabolic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0009220 pyrimidine ribonucleotide biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LF383891 - JP 2014500723-A/191394: Polycomb-Associated Non-Coding RNAs.
AF087865 - Homo sapiens UMP-CMPK mRNA, complete cds.
AF112216 - Homo sapiens UMP-CMP kinase mRNA, complete cds.
AK223014 - Homo sapiens mRNA for UMP-CMP kinase variant, clone: HSI12327.
AF110643 - Homo sapiens UMP-CMP kinase mRNA, complete cds.
AK298502 - Homo sapiens cDNA FLJ53623 complete cds, moderately similar to Homo sapiens cytidylate kinase (CMPK), mRNA.
AK294294 - Homo sapiens cDNA FLJ52483 complete cds, highly similar to Homo sapiens cytidylate kinase (CMPK), mRNA.
AF070416 - Homo sapiens UMP-CMP kinase mRNA, complete cds.
AK025258 - Homo sapiens cDNA: FLJ21605 fis, clone COL07274, highly similar to AF070416 Homo sapiens UMP-CMP kinase mRNA.
AK293238 - Homo sapiens cDNA FLJ53966 complete cds, moderately similar to Homo sapiens cytidylate kinase (CMPK), mRNA.
AK312693 - Homo sapiens cDNA, FLJ93091, Homo sapiens UMP-CMP kinase (UMP-CMPK), mRNA.
BC014961 - Homo sapiens cytidine monophosphate (UMP-CMP) kinase 1, cytosolic, mRNA (cDNA clone MGC:23020 IMAGE:4901714), complete cds.
AB528698 - Synthetic construct DNA, clone: pF1KB6930, Homo sapiens CMPK1 gene for cytidine monophosphate (UMP-CMP) kinase 1, cytosolic, without stop codon, in Flexi system.
DQ895408 - Synthetic construct Homo sapiens clone IMAGE:100009868; FLH184107.01L; RZPDo839C04143D cytidylate kinase (CMPK) gene, encodes complete protein.
DQ895409 - Synthetic construct Homo sapiens clone IMAGE:100009869; FLH263669.01L; RZPDo839C05143D cytidylate kinase (CMPK) gene, encodes complete protein.
DQ892213 - Synthetic construct clone IMAGE:100004843; FLH184111.01X; RZPDo839C04144D cytidylate kinase (CMPK) gene, encodes complete protein.
KJ898945 - Synthetic construct Homo sapiens clone ccsbBroadEn_08339 CMPK1 gene, encodes complete protein.
AF259961 - Homo sapiens cytidine monophosphate kinase CMP mRNA, complete cds.
MA619468 - JP 2018138019-A/191394: Polycomb-Associated Non-Coding RNAs.
BC017806 - Homo sapiens cytidine monophosphate (UMP-CMP) kinase 1, cytosolic, mRNA (cDNA clone IMAGE:4618136), with apparent retained intron.
LF356152 - JP 2014500723-A/163655: Polycomb-Associated Non-Coding RNAs.
LF356151 - JP 2014500723-A/163654: Polycomb-Associated Non-Coding RNAs.
LF356150 - JP 2014500723-A/163653: Polycomb-Associated Non-Coding RNAs.
LF356149 - JP 2014500723-A/163652: Polycomb-Associated Non-Coding RNAs.
MA591729 - JP 2018138019-A/163655: Polycomb-Associated Non-Coding RNAs.
MA591728 - JP 2018138019-A/163654: Polycomb-Associated Non-Coding RNAs.
MA591727 - JP 2018138019-A/163653: Polycomb-Associated Non-Coding RNAs.
MA591726 - JP 2018138019-A/163652: Polycomb-Associated Non-Coding RNAs.
LF356148 - JP 2014500723-A/163651: Polycomb-Associated Non-Coding RNAs.
JD273849 - Sequence 254873 from Patent EP1572962.
JD167325 - Sequence 148349 from Patent EP1572962.
JD240152 - Sequence 221176 from Patent EP1572962.
JD379935 - Sequence 360959 from Patent EP1572962.
JD037292 - Sequence 18316 from Patent EP1572962.
JD305460 - Sequence 286484 from Patent EP1572962.
JD378843 - Sequence 359867 from Patent EP1572962.
JD341143 - Sequence 322167 from Patent EP1572962.
JD312945 - Sequence 293969 from Patent EP1572962.
JD562559 - Sequence 543583 from Patent EP1572962.
JD284001 - Sequence 265025 from Patent EP1572962.
JD368378 - Sequence 349402 from Patent EP1572962.
JD303538 - Sequence 284562 from Patent EP1572962.
JD046170 - Sequence 27194 from Patent EP1572962.
JD344893 - Sequence 325917 from Patent EP1572962.
JD435976 - Sequence 417000 from Patent EP1572962.
JD510721 - Sequence 491745 from Patent EP1572962.
JD224029 - Sequence 205053 from Patent EP1572962.
JD502953 - Sequence 483977 from Patent EP1572962.
MA591725 - JP 2018138019-A/163651: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-7176 - UTP and CTP de novo biosynthesis
PWY-7197 - pyrimidine deoxyribonucleotide phosphorylation
PWY-7200 - superpathway of pyrimidine deoxyribonucleoside salvage
PWY-7205 - CMP phosphorylation
PWY-7211 - superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
PWY0-162 - superpathway of pyrimidine ribonucleotides de novo biosynthesis

Reactome (by CSHL, EBI, and GO)

Protein P30085 (Reactome details) participates in the following event(s):

R-HSA-73548 (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)
R-HSA-75125 (d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)
R-HSA-74220 (d)AMP + ATP <=> (d)ADP + ADP (AK1)
R-HSA-110141 (d)ADP + ADP <=> (d)AMP + ATP (AK1)
R-HSA-499943 Interconversion of nucleotide di- and triphosphates
R-HSA-15869 Metabolism of nucleotides
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B2R6S5, B4DPU7, CMK, CMPK , CMPK1 , E9PGI8, ENST00000371873.1, ENST00000371873.2, ENST00000371873.3, ENST00000371873.4, ENST00000371873.5, ENST00000371873.6, ENST00000371873.7, ENST00000371873.8, ENST00000371873.9, KCY_HUMAN, NM_016308, P30085, Q53GB7, Q5SVZ0, Q96C07, Q9UBQ8, Q9UIA2, uc318jlz.1, uc318jlz.2, UCK, UMK, UMPK
UCSC ID: ENST00000371873.10_3
RefSeq Accession: NM_001366135.1
Protein: P30085 (aka KCY_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.