Human Gene CLDN4 (ENST00000340958.4_5) from GENCODE V47lift37
  Description: claudin 4 (from RefSeq NM_001305.5)
Gencode Transcript: ENST00000340958.4_5
Gencode Gene: ENSG00000189143.10_9
Transcript (Including UTRs)
   Position: hg19 chr7:73,245,326-73,247,020 Size: 1,695 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr7:73,245,532-73,246,161 Size: 630 Coding Exon Count: 1 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:73,245,326-73,247,020)mRNA (may differ from genome)Protein (209 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CLDN4
Diseases sorted by gene-association score: williams-beuren syndrome (10), gastric adenocarcinoma (4), ovarian cancer, somatic (4), peritoneal serous papillary adenocarcinoma (3), pancreatic cancer (3), peritoneal serous adenocarcinoma (2), stomach cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 91.28 RPKM in Colon - Transverse
Total median expression: 538.68 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -64.80206-0.315 Picture PostScript Text
3' UTR -386.00859-0.449 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006187 - Claudin
IPR003550 - Claudin4
IPR017974 - Claudin_CS
IPR004031 - PMP22/EMP/MP20/Claudin

Pfam Domains:
PF00822 - PMP-22/EMP/MP20/Claudin family
PF13903 - PMP-22/EMP/MP20/Claudin tight junction

ModBase Predicted Comparative 3D Structure on Q75L80
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity
GO:0005254 chloride channel activity

Biological Process:
GO:0007565 female pregnancy
GO:0007623 circadian rhythm
GO:0032570 response to progesterone
GO:0070293 renal absorption
GO:1902476 chloride transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016327 apicolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0030054 cell junction


-  Descriptions from all associated GenBank mRNAs
  AK126462 - Homo sapiens cDNA FLJ44498 fis, clone UTERU3000645, highly similar to Claudin-4.
AK126315 - Homo sapiens cDNA FLJ44338 fis, clone TRACH3004786, highly similar to Claudin-4.
AK026651 - Homo sapiens cDNA: FLJ22998 fis, clone KAT11985, highly similar to AB000712 Homo sapiens hCPE-R mRNA for CPE-receptor.
AK124076 - Homo sapiens cDNA FLJ42082 fis, clone TCERX2000171, highly similar to CLAUDIN-4.
LF206974 - JP 2014500723-A/14477: Polycomb-Associated Non-Coding RNAs.
BC000671 - Homo sapiens claudin 4, mRNA (cDNA clone MGC:1778 IMAGE:3349211), complete cds.
JD437285 - Sequence 418309 from Patent EP1572962.
AB000712 - Homo sapiens hCPE-R mRNA for CPE-receptor, complete cds.
JD512915 - Sequence 493939 from Patent EP1572962.
JD190897 - Sequence 171921 from Patent EP1572962.
JD069334 - Sequence 50358 from Patent EP1572962.
EU831527 - Synthetic construct Homo sapiens clone HAIB:100066556; DKFZo004C1118 claudin 4 protein (CLDN4) gene, encodes complete protein.
EU831435 - Synthetic construct Homo sapiens clone HAIB:100066464; DKFZo008C1117 claudin 4 protein (CLDN4) gene, encodes complete protein.
BT006989 - Homo sapiens claudin 4 mRNA, complete cds.
KJ896635 - Synthetic construct Homo sapiens clone ccsbBroadEn_06029 CLDN4 gene, encodes complete protein.
JD059043 - Sequence 40067 from Patent EP1572962.
LF359835 - JP 2014500723-A/167338: Polycomb-Associated Non-Coding RNAs.
CS123434 - Sequence 5 from Patent WO2005058362.
JD325995 - Sequence 307019 from Patent EP1572962.
JD549839 - Sequence 530863 from Patent EP1572962.
JD519761 - Sequence 500785 from Patent EP1572962.
JD480692 - Sequence 461716 from Patent EP1572962.
JD123829 - Sequence 104853 from Patent EP1572962.
JD057847 - Sequence 38871 from Patent EP1572962.
JD172625 - Sequence 153649 from Patent EP1572962.
JD406342 - Sequence 387366 from Patent EP1572962.
JD197239 - Sequence 178263 from Patent EP1572962.
JD080767 - Sequence 61791 from Patent EP1572962.
JD222633 - Sequence 203657 from Patent EP1572962.
JD053378 - Sequence 34402 from Patent EP1572962.
JD386652 - Sequence 367676 from Patent EP1572962.
JD134840 - Sequence 115864 from Patent EP1572962.
JD351226 - Sequence 332250 from Patent EP1572962.
JD124934 - Sequence 105958 from Patent EP1572962.
JD346010 - Sequence 327034 from Patent EP1572962.
JD484849 - Sequence 465873 from Patent EP1572962.
JD040267 - Sequence 21291 from Patent EP1572962.
JD318645 - Sequence 299669 from Patent EP1572962.
JD347331 - Sequence 328355 from Patent EP1572962.
JD162682 - Sequence 143706 from Patent EP1572962.
JD540235 - Sequence 521259 from Patent EP1572962.
JD472934 - Sequence 453958 from Patent EP1572962.
JD135260 - Sequence 116284 from Patent EP1572962.
LF359836 - JP 2014500723-A/167339: Polycomb-Associated Non-Coding RNAs.
MA442551 - JP 2018138019-A/14477: Polycomb-Associated Non-Coding RNAs.
MA595412 - JP 2018138019-A/167338: Polycomb-Associated Non-Coding RNAs.
MA595413 - JP 2018138019-A/167339: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: CLDN4 , ENST00000340958.1, ENST00000340958.2, ENST00000340958.3, hCG_1737330 , NM_001305, Q75L80, Q75L80_HUMAN, uc317vwd.1, uc317vwd.2
UCSC ID: ENST00000340958.4_5
RefSeq Accession: NM_001305.5
Protein: Q75L80

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.