Human Gene CHERP (ENST00000546361.7_14) from GENCODE V47lift37

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Description: calcium homeostasis endoplasmic reticulum protein (from RefSeq NM_006387.6)
Gencode Transcript: ENST00000546361.7_14
Gencode Gene: ENSG00000085872.15_17
Transcript (Including UTRs)
Position: hg19 chr19:16,628,705-16,653,248 Size: 24,544 Total Exon Count: 17 Strand: -
Coding Region
Position: hg19 chr19:16,629,970-16,653,189 Size: 23,220 Coding Exon Count: 17

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:16,628,705-16,653,248)			mRNA (may differ from genome)		Protein (916 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: CHERP_HUMAN DESCRIPTION: RecName: Full=Calcium homeostasis endoplasmic reticulum protein; AltName: Full=ERPROT 213-21; AltName: Full=SR-related CTD-associated factor 6; FUNCTION: Involved in calcium homeostasis, growth and proliferation. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Distributed throughout the cytoplasm and also localizes to the perinuclear region of both human erythroleukemia (HEL) cells and Jurkat cells. Colocalizes with ITPR1. TISSUE SPECIFICITY: Expressed in brain, placenta, lung, liver, kidney, pancreas, cardiac and skeletal muscle, and in cultured HEL and Dami cells. SIMILARITY: Contains 1 CID domain. SIMILARITY: Contains 1 G-patch domain. SIMILARITY: Contains 1 SURP motif repeat. SEQUENCE CAUTION: Sequence=AAB53327.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH21294.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA69591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA69591.1; Type=Frameshift; Positions=450;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C009618 O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate D013749 Tetrachlorodibenzodioxin C524733 17-ethynyl-5-androstene-3, 7, 17-triol C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene D000082 Acetaminophen D002995 Clofibric Acid D004052 Diethylnitrosamine C006780 bisphenol A C018021 cobaltous chloride

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 18.32 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 481.28 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-21.20	59	-0.359	Picture	PostScript	Text
3' UTR	-430.60	1265	-0.340	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR008942 - ENTH_VHS
IPR000467 - G_patch_dom
IPR006903 - RNA_pol_II-bd
IPR006569 - RNA_polymerase_II_lsu_CTD
IPR000061 - Surp

Pfam Domains:
PF01585 - G-patch domain
PF01805 - Surp module
PF04818 - CID domain

SCOP Domains:
48464 - ENTH/VHS domain
109905 - Surp module (SWAP domain)

ModBase Predicted Comparative 3D Structure on Q8IWX8


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003676 nucleic acid binding GO:0003723 RNA binding GO:0005515 protein binding GO:0044325 ion channel binding Biological Process: GO:0000398 mRNA splicing, via spliceosome GO:0006396 RNA processing GO:0006874 cellular calcium ion homeostasis GO:0007399 nervous system development GO:0008285 negative regulation of cell proliferation GO:0051209 release of sequestered calcium ion into cytosol GO:0070886 positive regulation of calcineurin-NFAT signaling cascade Cellular Component: GO:0005654 nucleoplasm GO:0005737 cytoplasm GO:0005783 endoplasmic reticulum GO:0016020 membrane GO:0033017 sarcoplasmic reticulum membrane GO:0048471 perinuclear region of cytoplasm

Descriptions from all associated GenBank mRNAs


	BC068564 - Homo sapiens cDNA clone IMAGE:30342277, ** WARNING: chimeric clone **. BC021294 - Homo sapiens calcium homeostasis endoplasmic reticulum protein, mRNA (cDNA clone MGC:29449 IMAGE:4053575), complete cds. U94836 - Homo sapiens ERPROT 213-21 mRNA, complete cds. AF536542 - Homo sapiens SR-related CTD associated factor 6 (SCAF6) mRNA, complete cds. AK296883 - Homo sapiens cDNA FLJ51520 complete cds, highly similar to Homo sapiens calcium homeostasis endoplasmic reticulum protein (CHERP), mRNA. Y08265 - H.sapiens mRNA for DAN26 protein, partial. BC001552 - Homo sapiens calcium homeostasis endoplasmic reticulum protein, mRNA (cDNA clone IMAGE:3457864). CU676910 - Synthetic construct Homo sapiens gateway clone IMAGE:100023422 5' read CHERP mRNA. BC035039 - Homo sapiens calcium homeostasis endoplasmic reticulum protein, mRNA (cDNA clone IMAGE:4827033), with apparent retained intron. AB209730 - Homo sapiens mRNA for calcium homeostasis endoplasmic reticulum protein variant protein. JD472945 - Sequence 453969 from Patent EP1572962. JD179465 - Sequence 160489 from Patent EP1572962. JD404553 - Sequence 385577 from Patent EP1572962. JD389269 - Sequence 370293 from Patent EP1572962. JD384994 - Sequence 366018 from Patent EP1572962. JD210089 - Sequence 191113 from Patent EP1572962. JD196302 - Sequence 177326 from Patent EP1572962. JD523506 - Sequence 504530 from Patent EP1572962. JD040118 - Sequence 21142 from Patent EP1572962. JD225166 - Sequence 206190 from Patent EP1572962. JD083988 - Sequence 65012 from Patent EP1572962. JD316512 - Sequence 297536 from Patent EP1572962. JD207882 - Sequence 188906 from Patent EP1572962. JD464137 - Sequence 445161 from Patent EP1572962. JD371086 - Sequence 352110 from Patent EP1572962. JD343812 - Sequence 324836 from Patent EP1572962. JD211703 - Sequence 192727 from Patent EP1572962. AK298408 - Homo sapiens cDNA FLJ51519 complete cds, highly similar to Homo sapiens calcium homeostasis endoplasmic reticulum protein (CHERP), mRNA. JD334320 - Sequence 315344 from Patent EP1572962. JD540349 - Sequence 521373 from Patent EP1572962. JD291385 - Sequence 272409 from Patent EP1572962. JD420649 - Sequence 401673 from Patent EP1572962. JD199180 - Sequence 180204 from Patent EP1572962. JD479426 - Sequence 460450 from Patent EP1572962. JD159849 - Sequence 140873 from Patent EP1572962. JD173205 - Sequence 154229 from Patent EP1572962. JD459015 - Sequence 440039 from Patent EP1572962. JD467363 - Sequence 448387 from Patent EP1572962. JD139280 - Sequence 120304 from Patent EP1572962. JD309023 - Sequence 290047 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q8IWX8 (Reactome details) participates in the following event(s): R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA

Other Names for This Gene


	Alternate Gene Symbols: CHERP , CHERP_HUMAN, DAN26 , ENST00000546361.1, ENST00000546361.2, ENST00000546361.3, ENST00000546361.4, ENST00000546361.5, ENST00000546361.6, NM_006387, O00302, Q4G0Y5, Q8IWX8, Q8WU30, Q99492, SCAF6 , uc324xfe.1, uc324xfe.2 UCSC ID: ENST00000546361.7_14 RefSeq Accession: NM_006387.6 Protein: Q8IWX8 (aka CHERP_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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