The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6I9V6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000082 G1/S transition of mitotic cell cycle GO:0001666 response to hypoxia GO:0001890 placenta development GO:0006813 potassium ion transport GO:0007050 cell cycle arrest GO:0007096 regulation of exit from mitosis GO:0007219 Notch signaling pathway GO:0007605 sensory perception of sound GO:0008219 cell death GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0009749 response to glucose GO:0014070 response to organic cyclic compound GO:0016310 phosphorylation GO:0031116 positive regulation of microtubule polymerization GO:0032355 response to estradiol GO:0042127 regulation of cell proliferation GO:0042493 response to drug GO:0043066 negative regulation of apoptotic process GO:0043200 response to amino acid GO:0043434 response to peptide hormone GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0046686 response to cadmium ion GO:0048839 inner ear development GO:0050680 negative regulation of epithelial cell proliferation GO:0051271 negative regulation of cellular component movement GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development GO:0071236 cellular response to antibiotic GO:0071407 cellular response to organic cyclic compound GO:1902746 regulation of lens fiber cell differentiation
LF213912 - JP 2014500723-A/21415: Polycomb-Associated Non-Coding RNAs. LF207431 - JP 2014500723-A/14934: Polycomb-Associated Non-Coding RNAs. AK312461 - Homo sapiens cDNA, FLJ92816, Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1)(CDKN1B), mRNA. JB837396 - Sequence 7 from Patent WO2013106494. JD219027 - Sequence 200051 from Patent EP1572962. BC001971 - Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1), mRNA (cDNA clone MGC:5304 IMAGE:3458141), complete cds. AK298335 - Homo sapiens cDNA FLJ51923 complete cds, highly similar to Cyclin-dependent kinase inhibitor 1B. JD116000 - Sequence 97024 from Patent EP1572962. JD201618 - Sequence 182642 from Patent EP1572962. AY004255 - Homo sapiens cdk inhibitor p27KIP1 mRNA, complete cds. LF366105 - JP 2014500723-A/173608: Polycomb-Associated Non-Coding RNAs. DQ596464 - Homo sapiens piRNA piR-34530, complete sequence. AB451423 - Homo sapiens CDKN1B mRNA for cyclin-dependent kinase inhibitor 1B, partial cds, clone: FLJ08132AAAF. AB463551 - Synthetic construct DNA, clone: pF1KB8369, Homo sapiens CDKN1B gene for cyclin-dependent kinase inhibitor 1B, without stop codon, in Flexi system. AM392564 - Synthetic construct Homo sapiens clone IMAGE:100002741 for hypothetical protein (CDKN1B gene). AM393540 - Synthetic construct Homo sapiens clone IMAGE:100002740 for hypothetical protein (CDKN1B gene). AM393634 - Synthetic construct Homo sapiens clone IMAGE:100002991 for hypothetical protein (CDKN1B gene). AM393862 - Synthetic construct Homo sapiens clone IMAGE:100002990 for hypothetical protein (CDKN1B gene). BT019553 - Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) mRNA, complete cds. BT019554 - Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) mRNA, complete cds. KJ896586 - Synthetic construct Homo sapiens clone ccsbBroadEn_05980 CDKN1B gene, encodes complete protein. KR709516 - Synthetic construct Homo sapiens clone CCSBHm_00002932 CDKN1B (CDKN1B) mRNA, encodes complete protein. KR709517 - Synthetic construct Homo sapiens clone CCSBHm_00002934 CDKN1B (CDKN1B) mRNA, encodes complete protein. KR709518 - Synthetic construct Homo sapiens clone CCSBHm_00002935 CDKN1B (CDKN1B) mRNA, encodes complete protein. AB451291 - Homo sapiens CDKN1B mRNA for cyclin-dependent kinase inhibitor 1B, complete cds, clone: FLJ08132AAAN. AF247551 - Homo sapiens cyclin-dependent kinase inhibitor p27kip1 mRNA, complete cds. CR457399 - Homo sapiens full open reading frame cDNA clone RZPDo834F0810D for gene CDKN1B, cyclin-dependent kinase inhibitor 1B (p27, Kip1); complete cds, incl. stopcodon. U10906 - Human cyclin-dependent kinase inhibitor p27kip1 mRNA, complete cds. AJ616234 - Homo sapiens partial mRNA for cyclin-dependent kinase inhibitor 1B (CDKN1B gene). LF366106 - JP 2014500723-A/173609: Polycomb-Associated Non-Coding RNAs. LF366108 - JP 2014500723-A/173611: Polycomb-Associated Non-Coding RNAs. JD539523 - Sequence 520547 from Patent EP1572962. FW573286 - JP 2010529847-A/7: Oligonucleotides for modulation of target RNA activity. FW573287 - JP 2010529847-A/8: Oligonucleotides for modulation of target RNA activity. JD294525 - Sequence 275549 from Patent EP1572962. JD472872 - Sequence 453896 from Patent EP1572962. JD373791 - Sequence 354815 from Patent EP1572962. JD292852 - Sequence 273876 from Patent EP1572962. JD377320 - Sequence 358344 from Patent EP1572962. FW573288 - JP 2010529847-A/9: Oligonucleotides for modulation of target RNA activity. JD367789 - Sequence 348813 from Patent EP1572962. JD305456 - Sequence 286480 from Patent EP1572962. LF366109 - JP 2014500723-A/173612: Polycomb-Associated Non-Coding RNAs. FW573289 - JP 2010529847-A/10: Oligonucleotides for modulation of target RNA activity. LF366110 - JP 2014500723-A/173613: Polycomb-Associated Non-Coding RNAs. JD544728 - Sequence 525752 from Patent EP1572962. MA449489 - JP 2018138019-A/21415: Polycomb-Associated Non-Coding RNAs. MA601682 - JP 2018138019-A/173608: Polycomb-Associated Non-Coding RNAs. MA601683 - JP 2018138019-A/173609: Polycomb-Associated Non-Coding RNAs. MA601685 - JP 2018138019-A/173611: Polycomb-Associated Non-Coding RNAs. MA601686 - JP 2018138019-A/173612: Polycomb-Associated Non-Coding RNAs. MA601687 - JP 2018138019-A/173613: Polycomb-Associated Non-Coding RNAs. MA443008 - JP 2018138019-A/14934: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_p27Pathway - Regulation of p27 Phosphorylation during Cell Cycle Progression h_cellcyclePathway - Cyclins and Cell Cycle Regulation h_ctcfPathway - CTCF: First Multivalent Nuclear Factor h_g1Pathway - Cell Cycle: G1/S Check Point h_mcmPathway - CDK Regulation of DNA Replication h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
