ID:CDIPT_HUMAN DESCRIPTION: RecName: Full=CDP-diacylglycerol--inositol 3-phosphatidyltransferase; EC=2.7.8.11; AltName: Full=Phosphatidylinositol synthase; Short=PI synthase; Short=PtdIns synthase; FUNCTION: Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. CATALYTIC ACTIVITY: CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol. COFACTOR: Magnesium. COFACTOR: Manganese. ENZYME REGULATION: Inhibited by PtdIns (product inhibition), phosphatidylinositol phosphate, and nucleoside di- and tri- phosphates. BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 9.0; Temperature dependence: Optimum temperature is 50 degrees Celsius; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi- pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Widely expressed. Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen. In fetus, expressed in kidney, liver, lung and brain. SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14735
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity GO:0005515 protein binding GO:0016740 transferase activity GO:0016780 phosphotransferase activity, for other substituted phosphate groups GO:0019992 diacylglycerol binding GO:0030145 manganese ion binding GO:0030246 carbohydrate binding GO:0043178 alcohol binding
Biological Process: GO:0006629 lipid metabolic process GO:0006661 phosphatidylinositol biosynthetic process GO:0008654 phospholipid biosynthetic process GO:0046341 CDP-diacylglycerol metabolic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
