ID:MRCKG_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase MRCK gamma; EC=2.7.11.1; AltName: Full=CDC42-binding protein kinase gamma; AltName: Full=DMPK-like gamma; AltName: Full=Myotonic dystrophy kinase-related CDC42-binding kinase gamma; Short=MRCK gamma; Short=MRCKG; Short=Myotonic dystrophy protein kinase-like gamma; AltName: Full=Myotonic dystrophy protein kinase-like alpha; FUNCTION: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation (By similarity). SUBUNIT: Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42 (By similarity). INTERACTION: Q9UHD2:TBK1; NbExp=2; IntAct=EBI-689124, EBI-356402; SUBCELLULAR LOCATION: Cytoplasm. Note=Concentrates at the leading edge of cells. TISSUE SPECIFICITY: Expressed in heart and skeletal muscle. SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. SIMILARITY: Contains 1 AGC-kinase C-terminal domain. SIMILARITY: Contains 1 CNH domain. SIMILARITY: Contains 1 CRIB domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6DT37
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
