Human Gene CCNB2 (ENST00000288207.7_4) from GENCODE V47lift37
  Description: cyclin B2 (from RefSeq NM_004701.4)
Gencode Transcript: ENST00000288207.7_4
Gencode Gene: ENSG00000157456.8_8
Transcript (Including UTRs)
   Position: hg19 chr15:59,397,345-59,417,244 Size: 19,900 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr15:59,397,468-59,417,076 Size: 19,609 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:59,397,345-59,417,244)mRNA (may differ from genome)Protein (398 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCNB2_HUMAN
DESCRIPTION: RecName: Full=G2/mitotic-specific cyclin-B2;
FUNCTION: Essential for the control of the cell cycle at the G2/M (mitosis) transition.
SUBUNIT: Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.
DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly destroyed at mitosis.
SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccnb2/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCNB2
Diseases sorted by gene-association score: anauxetic dysplasia 1 (4), breast cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 62.14 RPKM in Testis
Total median expression: 164.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.20123-0.319 Picture PostScript Text
3' UTR -30.70168-0.183 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013763 - Cyclin-like
IPR014400 - Cyclin_A/B/D/E
IPR004367 - Cyclin_C
IPR006671 - Cyclin_N

Pfam Domains:
PF00134 - Cyclin, N-terminal domain
PF02984 - Cyclin, C-terminal domain

SCOP Domains:
47954 - Cyclin-like

ModBase Predicted Comparative 3D Structure on O95067
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
  Ensembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0045296 cadherin binding

Biological Process:
GO:0000086 G2/M transition of mitotic cell cycle
GO:0001701 in utero embryonic development
GO:0007049 cell cycle
GO:0007077 mitotic nuclear envelope disassembly
GO:0040007 growth
GO:0043029 T cell homeostasis
GO:0048538 thymus development
GO:0051301 cell division
GO:0051726 regulation of cell cycle

Cellular Component:
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  LF384561 - JP 2014500723-A/192064: Polycomb-Associated Non-Coding RNAs.
AK001404 - Homo sapiens cDNA FLJ10542 fis, clone NT2RP2001397, highly similar to G2/mitotic-specific cyclin-B2.
AL080146 - Homo sapiens mRNA; cDNA DKFZp434B174 (from clone DKFZp434B174).
BC105086 - Homo sapiens cyclin B2, mRNA (cDNA clone MGC:132746 IMAGE:8144089), complete cds.
BC105112 - Homo sapiens cyclin B2, mRNA (cDNA clone MGC:132772 IMAGE:8144115), complete cds.
AF087910 - Homo sapiens mitotic specific cyclin B2 mRNA, complete cds.
AK222611 - Homo sapiens mRNA for cyclin B2 variant, clone: CAS09751.
JD257409 - Sequence 238433 from Patent EP1572962.
AB020981 - Homo sapiens mRNA for cyclin B2, complete cds.
JD299853 - Sequence 280877 from Patent EP1572962.
AF002822 - Human cyclin B2 mRNA, complete cds.
AB587333 - Synthetic construct DNA, clone: pF1KB8567, Homo sapiens CCNB2 gene for cyclin B2, without stop codon, in Flexi system.
AM393577 - Synthetic construct Homo sapiens clone IMAGE:100001642 for hypothetical protein (CCNB2 gene).
BT019458 - Homo sapiens cyclin B2 mRNA, complete cds.
CR533527 - Homo sapiens full open reading frame cDNA clone RZPDo834G0119D for gene CCNB2, cyclin B2; complete cds, incl. stopcodon.
AM851054 - Homo sapiens mRNA for cyclin B2 (CCNB2V gene), short variant.
DQ586471 - Homo sapiens piRNA piR-53583, complete sequence.
DQ571127 - Homo sapiens piRNA piR-31239, complete sequence.
LF377530 - JP 2014500723-A/185033: Polycomb-Associated Non-Coding RNAs.
JD184581 - Sequence 165605 from Patent EP1572962.
MA620138 - JP 2018138019-A/192064: Polycomb-Associated Non-Coding RNAs.
MA613107 - JP 2018138019-A/185033: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_EfpPathway - Estrogen-responsive protein Efp controls cell cycle and breast tumors growth

Reactome (by CSHL, EBI, and GO)

Protein O95067 (Reactome details) participates in the following event(s):

R-HSA-170057 Formation of Cyclin B:Cdc2 complexes
R-HSA-170161 Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B
R-HSA-170055 Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes
R-HSA-2172183 Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB
R-NUL-2422970 Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB
R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres
R-HSA-2468293 CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms
R-HSA-2514854 CDK1 phosphorylates condensin I
R-HSA-2984220 CDK1:CCNB phosphorylates NEK9
R-HSA-2990882 CDK1 phosphorylates NUP98
R-HSA-4086410 CDK1 phosphorylates BORA
R-HSA-8852306 Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends
R-HSA-156711 Polo-like kinase mediated events
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69275 G2/M Transition
R-HSA-69478 G2/M DNA replication checkpoint
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2514853 Condensation of Prometaphase Chromosomes
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-69481 G2/M Checkpoints
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-68875 Mitotic Prophase
R-HSA-68877 Mitotic Prometaphase
R-HSA-2980766 Nuclear Envelope Breakdown
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-1640170 Cell Cycle
R-HSA-68886 M Phase

-  Other Names for This Gene
  Alternate Gene Symbols: B3KM93, CCNB2_HUMAN, ENST00000288207.1, ENST00000288207.2, ENST00000288207.3, ENST00000288207.4, ENST00000288207.5, ENST00000288207.6, NM_004701, O95067, Q6FI99, uc317kpf.1, uc317kpf.2
UCSC ID: ENST00000288207.7_4
RefSeq Accession: NM_004701.4
Protein: O95067 (aka CCNB2_HUMAN or CGB2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.