Human Gene CCDC117 (ENST00000249064.9_4) from GENCODE V47lift37

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Description: coiled-coil domain containing 117, transcript variant 1 (from RefSeq NM_173510.4)
Gencode Transcript: ENST00000249064.9_4
Gencode Gene: ENSG00000159873.10_7
Transcript (Including UTRs)
Position: hg19 chr22:29,168,683-29,185,283 Size: 16,601 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr22:29,168,838-29,182,314 Size: 13,477 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr22:29,168,683-29,185,283)			mRNA (may differ from genome)		Protein (279 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: CC117_HUMAN DESCRIPTION: RecName: Full=Coiled-coil domain-containing protein 117;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D010634 Phenobarbital D013749 Tetrachlorodibenzodioxin C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid C017906 3-dinitrobenzene D000082 Acetaminophen D019256 Cadmium Chloride D002794 Choline D019327 Copper Sulfate D003375 Coumestrol more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 22.67 RPKM in Testis Total median expression: 303.43 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-74.60	155	-0.481	Picture	PostScript	Text
3' UTR	-810.60	2969	-0.273	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

Pfam Domains:
PF15810 - Coiled-coil domain-containing protein 117

ModBase Predicted Comparative 3D Structure on Q8IWD4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding

Descriptions from all associated GenBank mRNAs


	AK289516 - Homo sapiens cDNA FLJ77855 complete cds. BC065549 - Homo sapiens coiled-coil domain containing 117, mRNA (cDNA clone MGC:70940 IMAGE:6045091), complete cds. BC053874 - Homo sapiens coiled-coil domain containing 117, mRNA (cDNA clone MGC:61737 IMAGE:5531689), complete cds. BC040488 - Homo sapiens coiled-coil domain containing 117, mRNA (cDNA clone MGC:33378 IMAGE:5272169), complete cds. AK302925 - Homo sapiens cDNA FLJ54991 complete cds. AK091133 - Homo sapiens cDNA FLJ33814 fis, clone CTONG2002766. AX746797 - Sequence 322 from Patent EP1308459. AK295140 - Homo sapiens cDNA FLJ54677 complete cds. CR456461 - Homo sapiens dJ366L4.1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ366L4.1.V2). AB528096 - Synthetic construct DNA, clone: pF1KE0509, Homo sapiens CCDC117 gene for coiled-coil domain containing 117, without stop codon, in Flexi system. CU013300 - Homo sapiens dJ366L4.C22.1, mRNA (cDNA clone IMAGE:100000078), complete cds, without stop codon, in Gateway system. CU691050 - Synthetic construct Homo sapiens gateway clone IMAGE:100023181 5' read CCDC117 mRNA. KJ895643 - Synthetic construct Homo sapiens clone ccsbBroadEn_05037 CCDC117 gene, encodes complete protein. CU013012 - Homo sapiens dJ366L4.C22.1, mRNA (cDNA clone IMAGE:100000174), complete cds, with stop codon, in Gateway system. AK302798 - Homo sapiens cDNA FLJ59662 complete cds. AK127794 - Homo sapiens cDNA FLJ45895 fis, clone OCBBF3023993. JD246027 - Sequence 227051 from Patent EP1572962. JD288225 - Sequence 269249 from Patent EP1572962. JD564973 - Sequence 545997 from Patent EP1572962. JD294714 - Sequence 275738 from Patent EP1572962. JD362118 - Sequence 343142 from Patent EP1572962. JD504066 - Sequence 485090 from Patent EP1572962. JD278723 - Sequence 259747 from Patent EP1572962. JD062162 - Sequence 43186 from Patent EP1572962. JD042757 - Sequence 23781 from Patent EP1572962. JD041486 - Sequence 22510 from Patent EP1572962. JD299992 - Sequence 281016 from Patent EP1572962. JD554753 - Sequence 535777 from Patent EP1572962. JD253230 - Sequence 234254 from Patent EP1572962. JD124440 - Sequence 105464 from Patent EP1572962. JD356533 - Sequence 337557 from Patent EP1572962. JD284915 - Sequence 265939 from Patent EP1572962. JD507315 - Sequence 488339 from Patent EP1572962. JD356419 - Sequence 337443 from Patent EP1572962. JD505894 - Sequence 486918 from Patent EP1572962. JD107612 - Sequence 88636 from Patent EP1572962. AK092636 - Homo sapiens cDNA FLJ35317 fis, clone PROST2011038. JD174742 - Sequence 155766 from Patent EP1572962. JD245013 - Sequence 226037 from Patent EP1572962. JD538690 - Sequence 519714 from Patent EP1572962. JD109037 - Sequence 90061 from Patent EP1572962. JD116405 - Sequence 97429 from Patent EP1572962. JD550465 - Sequence 531489 from Patent EP1572962. JD109655 - Sequence 90679 from Patent EP1572962. JD168427 - Sequence 149451 from Patent EP1572962. JD090373 - Sequence 71397 from Patent EP1572962. JD165860 - Sequence 146884 from Patent EP1572962. JD303643 - Sequence 284667 from Patent EP1572962. JD174512 - Sequence 155536 from Patent EP1572962. JD426845 - Sequence 407869 from Patent EP1572962. JD516274 - Sequence 497298 from Patent EP1572962. JD433339 - Sequence 414363 from Patent EP1572962. JD046417 - Sequence 27441 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A8K0F1, B7Z2V1, B7Z860, CC117_HUMAN, CCDC117 , ENST00000249064.1, ENST00000249064.2, ENST00000249064.3, ENST00000249064.4, ENST00000249064.5, ENST00000249064.6, ENST00000249064.7, ENST00000249064.8, NM_173510, Q6ICA7, Q8IWD4, Q8N278, uc317eyv.1, uc317eyv.2 UCSC ID: ENST00000249064.9_4 RefSeq Accession: NM_173510.4 Protein: Q8IWD4 (aka CC117_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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