Human Gene CATSPERG (ENST00000409235.8_6) from GENCODE V47lift37
  Description: cation channel sperm associated auxiliary subunit gamma, transcript variant 1 (from RefSeq NM_021185.5)
Gencode Transcript: ENST00000409235.8_6
Gencode Gene: ENSG00000099338.23_10
Transcript (Including UTRs)
   Position: hg19 chr19:38,826,470-38,861,583 Size: 35,114 Total Exon Count: 29 Strand: +
Coding Region
   Position: hg19 chr19:38,827,875-38,861,432 Size: 33,558 Coding Exon Count: 28 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:38,826,470-38,861,583)mRNA (may differ from genome)Protein (1159 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CTSRG_HUMAN
DESCRIPTION: RecName: Full=Cation channel sperm-associated protein subunit gamma; Flags: Precursor;
FUNCTION: Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (By similarity).
SUBUNIT: Component of the CatSper complex (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
SIMILARITY: Belongs to the CATSPERG family.
SEQUENCE CAUTION: Sequence=BAC87333.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 37.68 RPKM in Testis
Total median expression: 63.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.8060-0.263 Picture PostScript Text
3' UTR -26.70151-0.177 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15064 - Cation channel sperm-associated protein subunit gamma

ModBase Predicted Comparative 3D Structure on Q6ZRH7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0035036 sperm-egg recognition

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0036128 CatSper complex
GO:0097228 sperm principal piece


-  Descriptions from all associated GenBank mRNAs
  BC033852 - Homo sapiens chromosome 19 open reading frame 15, mRNA (cDNA clone IMAGE:5165842), partial cds.
AK128220 - Homo sapiens cDNA FLJ46353 fis, clone TESTI4048545.
BC060889 - Homo sapiens chromosome 19 open reading frame 15, mRNA (cDNA clone IMAGE:5271459), with apparent retained intron.
BC094785 - Homo sapiens chromosome 19 open reading frame 15, mRNA (cDNA clone IMAGE:5270737).
AL133023 - Homo sapiens mRNA; cDNA DKFZp434A1022 (from clone DKFZp434A1022).
JD026820 - Sequence 7844 from Patent EP1572962.
JD034133 - Sequence 15157 from Patent EP1572962.
AK310460 - Homo sapiens cDNA, FLJ17502.
BC053587 - Homo sapiens cDNA clone IMAGE:5244704, partial cds.
BC109035 - Homo sapiens chromosome 19 open reading frame 15, mRNA (cDNA clone MGC:125664 IMAGE:40028284), complete cds.
JD019093 - Sequence 117 from Patent EP1572962.
JD027698 - Sequence 8722 from Patent EP1572962.
AK128039 - Homo sapiens cDNA FLJ46158 fis, clone TESTI4002003.
AK096218 - Homo sapiens cDNA FLJ38899 fis, clone NT2NE2001005.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6ZRH7 (Reactome details) participates in the following event(s):

R-HSA-2534388 Progesterone Activation Of CatSper
R-HSA-2534359 CatSper Channel Mediated Calcium Transport
R-HSA-1300642 Sperm Motility And Taxes
R-HSA-1187000 Fertilization
R-HSA-1474165 Reproduction

-  Other Names for This Gene
  Alternate Gene Symbols: A6NEG6, C19orf15, CATSPERG , CTSRG_HUMAN, ENST00000409235.1, ENST00000409235.2, ENST00000409235.3, ENST00000409235.4, ENST00000409235.5, ENST00000409235.6, ENST00000409235.7, NM_021185, Q659E1, Q6ZRH7, uc319flt.1, uc319flt.2
UCSC ID: ENST00000409235.8_6
RefSeq Accession: NM_021185.5
Protein: Q6ZRH7 (aka CTSRG_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.