ID:CTSR2_HUMAN DESCRIPTION: RecName: Full=Cation channel sperm-associated protein 2; Short=CatSper2; FUNCTION: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. SUBUNIT: Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with Ca(v)3.3/CACNA1I, leading to suppress T- type calcium channel activity. INTERACTION: Q9P0X4:CACNA1I; NbExp=3; IntAct=EBI-2215024, EBI-1220829; SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane; Multi-pass membrane protein (By similarity). Note=Specifically located in the principal piece of sperm tail. TISSUE SPECIFICITY: Testis-specific. DISEASE: Defects in CATSPER2 are a cause of deafness-infertility syndrome (DIS) [MIM:611102]. DIS is characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. SIMILARITY: Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96P56
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005216 ion channel activity GO:0005227 calcium activated cation channel activity GO:0005244 voltage-gated ion channel activity GO:0005248 voltage-gated sodium channel activity GO:0005262 calcium channel activity GO:0005515 protein binding
Biological Process: GO:0006811 ion transport GO:0006816 calcium ion transport GO:0007275 multicellular organism development GO:0007283 spermatogenesis GO:0019228 neuronal action potential GO:0030154 cell differentiation GO:0030317 flagellated sperm motility GO:0034765 regulation of ion transmembrane transport GO:0035036 sperm-egg recognition GO:0035725 sodium ion transmembrane transport GO:0055085 transmembrane transport GO:0070588 calcium ion transmembrane transport GO:0086010 membrane depolarization during action potential
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
