ID:CAN10_HUMAN DESCRIPTION: RecName: Full=Calpain-10; EC=3.4.22.-; AltName: Full=Calcium-activated neutral proteinase 10; Short=CANP 10; FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. CATALYTIC ACTIVITY: Broad endopeptidase specificity. TISSUE SPECIFICITY: Ubiquitous. DISEASE: Defects in CAPN10 are a cause of susceptibility to diabetes mellitus non-insulin-dependent type 1 (NIDDM1) [MIM:601283]. It is a multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. SIMILARITY: Belongs to the peptidase C2 family. SIMILARITY: Contains 1 calpain catalytic domain. SEQUENCE CAUTION: Sequence=BAB47474.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HC96
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006508 proteolysis GO:0006921 cellular component disassembly involved in execution phase of apoptosis GO:0031532 actin cytoskeleton reorganization GO:0032024 positive regulation of insulin secretion GO:0032388 positive regulation of intracellular transport GO:0032869 cellular response to insulin stimulus GO:0046326 positive regulation of glucose import GO:0097050 type B pancreatic cell apoptotic process GO:2000676 positive regulation of type B pancreatic cell apoptotic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
