Human Gene CALCRL (ENST00000392370.8_7) from GENCODE V47lift37
  Description: calcitonin receptor like receptor, transcript variant 1 (from RefSeq NM_005795.6)
Gencode Transcript: ENST00000392370.8_7
Gencode Gene: ENSG00000064989.13_12
Transcript (Including UTRs)
   Position: hg19 chr2:188,206,691-188,312,979 Size: 106,289 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr2:188,210,911-188,250,322 Size: 39,412 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:188,206,691-188,312,979)mRNA (may differ from genome)Protein (461 aa)
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-  Comments and Description Text from UniProtKB
  ID: CALRL_HUMAN
DESCRIPTION: RecName: Full=Calcitonin gene-related peptide type 1 receptor; Short=CGRP type 1 receptor; AltName: Full=Calcitonin receptor-like receptor; Flags: Precursor;
FUNCTION: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
SUBUNIT: Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Predominantly expressed in the lung and heart.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
SEQUENCE CAUTION: Sequence=BAF84319.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CALCRL
Diseases sorted by gene-association score: pheochromocytoma (3), migraine with or without aura 1 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.57 RPKM in Lung
Total median expression: 191.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -96.67506-0.191 Picture PostScript Text
3' UTR -852.404220-0.202 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003287 - GCPR_2_calcitonin_rcpt_fam
IPR017981 - GPCR_2-like
IPR003289 - GPCR_2_CGRP1_rcpt
IPR001879 - GPCR_2_extracellular_dom
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF02793 - Hormone receptor domain

SCOP Domains:
81321 - Family A G protein-coupled receptor-like
111418 - Hormone receptor domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3AQF - X-ray MuPIT 3N7P - X-ray MuPIT 3N7R - X-ray MuPIT 3N7S - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q16602
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001605 adrenomedullin receptor activity
GO:0001635 calcitonin gene-related peptide receptor activity
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004948 calcitonin receptor activity
GO:0005515 protein binding
GO:0008565 protein transporter activity
GO:1990409 adrenomedullin binding

Biological Process:
GO:0001525 angiogenesis
GO:0006816 calcium ion transport
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0015031 protein transport
GO:0031623 receptor internalization
GO:0045986 negative regulation of smooth muscle contraction
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0071329 cellular response to sucrose stimulus
GO:1990408 calcitonin gene-related peptide receptor signaling pathway
GO:1990410 adrenomedullin receptor signaling pathway

Cellular Component:
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:1903143 adrenomedullin receptor complex
GO:1990406 CGRP receptor complex


-  Descriptions from all associated GenBank mRNAs
  FW340061 - Screening.
L76380 - Homo sapiens (clone HSNME29) CGRP type 1 receptor mRNA, complete cds.
U17473 - Human calcitonin-like receptor mRNA, complete cds.
AK292998 - Homo sapiens cDNA FLJ75294 complete cds, highly similar to Human calcitonin-like receptor mRNA.
AK291630 - Homo sapiens cDNA FLJ78076 complete cds, highly similar to Homo sapiens calcitonin receptor-like (CALCRL), mRNA.
AY389506 - Homo sapiens calcitonin receptor-like protein (CALCRL) mRNA, complete cds.
BC156827 - Synthetic construct Homo sapiens clone IMAGE:100062574, MGC:190568 calcitonin receptor-like (CALCRL) mRNA, encodes complete protein.
JD050060 - Sequence 31084 from Patent EP1572962.
JD149951 - Sequence 130975 from Patent EP1572962.
JD093193 - Sequence 74217 from Patent EP1572962.
JD357006 - Sequence 338030 from Patent EP1572962.
JD365216 - Sequence 346240 from Patent EP1572962.
JD450722 - Sequence 431746 from Patent EP1572962.
JD278571 - Sequence 259595 from Patent EP1572962.
JD294500 - Sequence 275524 from Patent EP1572962.
JD364108 - Sequence 345132 from Patent EP1572962.
DL491655 - Novel nucleic acids.
DL490241 - Novel nucleic acids.
DQ280491 - Homo sapiens hypothetical CALCRL-related pioneer protein mRNA, complete cds.
JD219164 - Sequence 200188 from Patent EP1572962.
JD182579 - Sequence 163603 from Patent EP1572962.
DQ280490 - Homo sapiens CALCRL mRNA, 5'UTR.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q16602 (Reactome details) participates in the following event(s):

R-HSA-420127 CGRP receptor can bind calcitonin gene-related peptides
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-420214 The adrenomedullin receptor can bind adrenomedullin and intermedin
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-419812 Calcitonin-like ligand receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A8K6G5, A8KAD3, CALCRL , CALRL_HUMAN, CGRPR, ENST00000392370.1, ENST00000392370.2, ENST00000392370.3, ENST00000392370.4, ENST00000392370.5, ENST00000392370.6, ENST00000392370.7, NM_005795, Q16602, Q53S02, Q53TS5, uc318vas.1, uc318vas.2
UCSC ID: ENST00000392370.8_7
RefSeq Accession: NM_005795.6
Protein: Q16602 (aka CALRL_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.