Human Gene GLMP (ENST00000362007.6_7) from GENCODE V47lift37
  Description: glycosylated lysosomal membrane protein, transcript variant 1 (from RefSeq NM_144580.3)
Gencode Transcript: ENST00000362007.6_7
Gencode Gene: ENSG00000198715.13_16
Transcript (Including UTRs)
   Position: hg19 chr1:156,262,479-156,265,470 Size: 2,992 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr1:156,262,835-156,265,436 Size: 2,602 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:156,262,479-156,265,470)mRNA (may differ from genome)Protein (406 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NCUG1_HUMAN
DESCRIPTION: RecName: Full=Lysosomal protein NCU-G1; Flags: Precursor;
SUBCELLULAR LOCATION: Lysosome membrane; Single-pass type I membrane protein.
INDUCTION: Transcription is activated by TFEB.
PTM: Highly N-glycosylated (By similarity).
CAUTION: According to PubMed:18021396, it binds DNA and acts as a transcription factor. However, the localization in lysosomes which was confirmed by different groups and the presence of transmembrane region strongly suggests that it does not have coactivator activity.
SEQUENCE CAUTION: Sequence=AAH11575.1; Type=Erroneous initiation; Sequence=CAI14165.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.91 RPKM in Adrenal Gland
Total median expression: 469.67 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.9034-0.262 Picture PostScript Text
3' UTR -126.80356-0.356 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15065 - Lysosomal transcription factor, NCU-G1

SCOP Domains:
140486 - PA2201 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q8WWB7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0044212 transcription regulatory region DNA binding

Biological Process:
GO:0030522 intracellular receptor signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF086351 - Homo sapiens full length insert cDNA clone ZD63A01.
LF206162 - JP 2014500723-A/13665: Polycomb-Associated Non-Coding RNAs.
AY358450 - Homo sapiens clone DNA110700 RGSV2553 (UNQ2553) mRNA, complete cds.
BC011575 - Homo sapiens chromosome 1 open reading frame 85, mRNA (cDNA clone IMAGE:4639306), partial cds.
BC036340 - Homo sapiens chromosome 1 open reading frame 85, mRNA (cDNA clone IMAGE:5187328), partial cds.
BC018757 - Homo sapiens chromosome 1 open reading frame 85, mRNA (cDNA clone MGC:31963 IMAGE:4850051), complete cds.
AK075349 - Homo sapiens cDNA PSEC0030 fis, clone NT2RP1000567, highly similar to Kidney predominant protein NCU-G1.
JD075955 - Sequence 56979 from Patent EP1572962.
JD403251 - Sequence 384275 from Patent EP1572962.
LF352088 - JP 2014500723-A/159591: Polycomb-Associated Non-Coding RNAs.
JD234738 - Sequence 215762 from Patent EP1572962.
AK296157 - Homo sapiens cDNA FLJ57118 complete cds.
JD506726 - Sequence 487750 from Patent EP1572962.
JD298693 - Sequence 279717 from Patent EP1572962.
JD394943 - Sequence 375967 from Patent EP1572962.
LF352087 - JP 2014500723-A/159590: Polycomb-Associated Non-Coding RNAs.
KJ895238 - Synthetic construct Homo sapiens clone ccsbBroadEn_04632 C1orf85 gene, encodes complete protein.
LF352086 - JP 2014500723-A/159589: Polycomb-Associated Non-Coding RNAs.
LF352083 - JP 2014500723-A/159586: Polycomb-Associated Non-Coding RNAs.
LF352081 - JP 2014500723-A/159584: Polycomb-Associated Non-Coding RNAs.
LF352078 - JP 2014500723-A/159581: Polycomb-Associated Non-Coding RNAs.
LF352076 - JP 2014500723-A/159579: Polycomb-Associated Non-Coding RNAs.
JD026815 - Sequence 7839 from Patent EP1572962.
JD030213 - Sequence 11237 from Patent EP1572962.
LF352075 - JP 2014500723-A/159578: Polycomb-Associated Non-Coding RNAs.
MA587665 - JP 2018138019-A/159591: Polycomb-Associated Non-Coding RNAs.
MA587664 - JP 2018138019-A/159590: Polycomb-Associated Non-Coding RNAs.
MA587663 - JP 2018138019-A/159589: Polycomb-Associated Non-Coding RNAs.
MA587660 - JP 2018138019-A/159586: Polycomb-Associated Non-Coding RNAs.
MA587658 - JP 2018138019-A/159584: Polycomb-Associated Non-Coding RNAs.
MA587655 - JP 2018138019-A/159581: Polycomb-Associated Non-Coding RNAs.
MA587653 - JP 2018138019-A/159579: Polycomb-Associated Non-Coding RNAs.
MA587652 - JP 2018138019-A/159578: Polycomb-Associated Non-Coding RNAs.
MA441739 - JP 2018138019-A/13665: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NH16, B4DJN4, C1orf85 , ENST00000362007.1, ENST00000362007.2, ENST00000362007.3, ENST00000362007.4, ENST00000362007.5, GLMP , GLMP_HUMAN, NM_144580, PSEC0030, Q5SZX4, Q6UX96, Q8IV07, Q8WWB7, Q96F65, uc318cma.1, uc318cma.2, UNQ2553/PRO6182
UCSC ID: ENST00000362007.6_7
RefSeq Accession: NM_144580.3
Protein: Q8WWB7 (aka NCUG1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.