ID:BRD4_HUMAN DESCRIPTION: RecName: Full=Bromodomain-containing protein 4; AltName: Full=Protein HUNK1; FUNCTION: Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). SUBUNIT: Associated with chromosomes during mitosis (By similarity). Interacts with bovine papillomavirus type 1 regulatory protein E2. INTERACTION: P62993:GRB2; NbExp=2; IntAct=EBI-723869, EBI-401755; P16333:NCK1; NbExp=2; IntAct=EBI-723869, EBI-389883; SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed. DISEASE: Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein. SIMILARITY: Contains 2 bromo domains. SIMILARITY: Contains 1 NET domain. SEQUENCE CAUTION: Sequence=AAC27978.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BRD4ID837ch19p13.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60885
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0006325 chromatin organization GO:0006338 chromatin remodeling GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006974 cellular response to DNA damage stimulus GO:0010971 positive regulation of G2/M transition of mitotic cell cycle GO:0016032 viral process GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050727 regulation of inflammatory response GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain GO:2000002 negative regulation of DNA damage checkpoint
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
