Human Gene BLID (ENST00000560104.2_6) from GENCODE V47lift37

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Description: BH3-like motif containing, cell death inducer (from RefSeq NM_001001786.3)
Gencode Transcript: ENST00000560104.2_6
Gencode Gene: ENSG00000259571.2_9
Transcript (Including UTRs)
Position: hg19 chr11:121,986,048-121,986,923 Size: 876 Total Exon Count: 1 Strand: -
Coding Region
Position: hg19 chr11:121,986,304-121,986,630 Size: 327 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:121,986,048-121,986,923)			mRNA (may differ from genome)		Protein (108 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: BLID_HUMAN DESCRIPTION: RecName: Full=BH3-like motif-containing cell death inducer; AltName: Full=Breast cancer cell protein 2; FUNCTION: Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death. SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion. Note=Lower abundance in mitochondrion than in cytoplasm. TISSUE SPECIFICITY: Ubiquitously expressed.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C045651 epigallocatechin gallate C027373 potassium chromate(VI)

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 0.13 RPKM in Ovary Total median expression: 0.88 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-74.90	293	-0.256	Picture	PostScript	Text
3' UTR	-35.80	256	-0.140	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

ModBase Predicted Comparative 3D Structure on Q8IZY5


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003674 molecular_function Biological Process: GO:0006915 apoptotic process GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Cellular Component: GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005829 cytosol

Descriptions from all associated GenBank mRNAs


	AF303179 - Homo sapiens BRCC2 mRNA, complete cds. JD313150 - Sequence 294174 from Patent EP1572962. JD122853 - Sequence 103877 from Patent EP1572962. BC130361 - Homo sapiens BH3-like motif containing, cell death inducer, mRNA (cDNA clone MGC:163233 IMAGE:40146392), complete cds. BC130363 - Homo sapiens BH3-like motif containing, cell death inducer, mRNA (cDNA clone MGC:163235 IMAGE:40146394), complete cds. HQ258713 - Synthetic construct Homo sapiens clone IMAGE:100072743 BH3-like motif containing, cell death inducer (BLID) gene, encodes complete protein. KJ896269 - Synthetic construct Homo sapiens clone ccsbBroadEn_05663 BLID gene, encodes complete protein. JD167757 - Sequence 148781 from Patent EP1572962. JD373106 - Sequence 354130 from Patent EP1572962. JD386367 - Sequence 367391 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A1L416, BLID_HUMAN, BRCC2, ENST00000560104.1, NM_001001786, Q8IZY5, uc325nsc.1, uc325nsc.2 UCSC ID: ENST00000560104.2_6 RefSeq Accession: NM_001001786.3 Protein: Q8IZY5 (aka BLID_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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