ID:BIRC6_HUMAN DESCRIPTION: RecName: Full=Baculoviral IAP repeat-containing protein 6; EC=6.3.2.-; AltName: Full=BIR repeat-containing ubiquitin-conjugating enzyme; Short=BRUCE; AltName: Full=Ubiquitin-conjugating BIR domain enzyme apollon; Short=APOLLON; FUNCTION: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. ENZYME REGULATION: Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9. SUBUNIT: Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8. INTERACTION: Q96A65:EXOC4; NbExp=3; IntAct=EBI-1765160, EBI-355383; Q02241:KIF23; NbExp=4; IntAct=EBI-1765160, EBI-306852; Q02750:MAP2K1; NbExp=2; IntAct=EBI-1765160, EBI-492564; P53350:PLK1; NbExp=3; IntAct=EBI-1765160, EBI-476768; SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane. Midbody. Endosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, centrosome. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. TISSUE SPECIFICITY: Expressed in brain cancer cells. DOMAIN: The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9. PTM: Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY. SIMILARITY: In the C-terminal section; belongs to the ubiquitin- conjugating enzyme family. SIMILARITY: Contains 1 BIR repeat. SEQUENCE CAUTION: Sequence=BAA86603.2; Type=Frameshift; Positions=2047; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BIRC6ID798ch2p22.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NR09
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001890 placenta development GO:0006468 protein phosphorylation GO:0006915 apoptotic process GO:0007049 cell cycle GO:0008284 positive regulation of cell proliferation GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0016567 protein ubiquitination GO:0032465 regulation of cytokinesis GO:0042127 regulation of cell proliferation GO:0043066 negative regulation of apoptotic process GO:0051301 cell division GO:0060711 labyrinthine layer development GO:0060712 spongiotrophoblast layer development GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
