ID:BCL9L_HUMAN DESCRIPTION: RecName: Full=B-cell CLL/lymphoma 9-like protein; Short=B-cell lymphoma 9-like protein; Short=BCL9-like protein; AltName: Full=Protein BCL9-2; FUNCTION: Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). SUBUNIT: Found in a complex with CDC73; CTNNB1 and PYGO1. Interacts with CTNNB1. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor. DOMAIN: Tne C-terminal domain is important for its transactivation activity (By similarity). SIMILARITY: Belongs to the BCL9 family. SEQUENCE CAUTION: Sequence=AAH33257.1; Type=Erroneous initiation; Sequence=BAC85500.1; Type=Erroneous initiation; Sequence=BAC85512.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86UU0
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AB094091 - Homo sapiens DLNB11 mRNA, complete cds. U84513 - Human velo-cardio-facial syndrome 22q11 region mRNA sequence. AY296059 - Homo sapiens BCL9-2 mRNA, complete cds. BC033257 - Homo sapiens B-cell CLL/lymphoma 9-like, mRNA (cDNA clone IMAGE:5457446), complete cds. AK122650 - Homo sapiens cDNA FLJ16081 fis, clone NT2RI2006686, weakly similar to E1A-ASSOCIATED PROTEIN P300. AK122882 - Homo sapiens cDNA FLJ16530 fis, clone OCBBF2021788, weakly similar to Homo sapiens mRNA for B-cell CLL/lymphoma 9. BC156197 - Synthetic construct Homo sapiens clone IMAGE:100061610, MGC:190050 B-cell CLL/lymphoma 9-like (BCL9L) mRNA, encodes complete protein. JD271282 - Sequence 252306 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q86UU0 (Reactome details) participates in the following event(s):
R-HSA-201712 Beta-catenin:TCF associates with BCL9 and PYGO R-HSA-3364014 Recruitment of SET1 methyltransferase complex R-HSA-3364026 SET1 complex trimethylates H3K4 at the MYC gene R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex R-HSA-3769402 Deactivation of the beta-catenin transactivating complex R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-195721 Signaling by WNT R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
