ID:VATH_HUMAN DESCRIPTION: RecName: Full=V-type proton ATPase subunit H; Short=V-ATPase subunit H; AltName: Full=Nef-binding protein 1; Short=NBP1; AltName: Full=Protein VMA13 homolog; AltName: Full=V-ATPase 50/57 kDa subunits; AltName: Full=Vacuolar proton pump subunit H; AltName: Full=Vacuolar proton pump subunit SFD; FUNCTION: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with HIV-1 Nef protein and AP2M1. TISSUE SPECIFICITY: Widely expressed. SIMILARITY: Belongs to the V-ATPase H subunit family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UI12
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK098305 - Homo sapiens cDNA FLJ40986 fis, clone UTERU2014898, highly similar to Vacuolar ATP synthase subunit H (EC 3.6.3.14). AF132945 - Homo sapiens CGI-11 protein mRNA, complete cds. BC007421 - Homo sapiens cDNA clone IMAGE:2966552, containing frame-shift errors. BC007454 - Homo sapiens cDNA clone IMAGE:2966552, containing frame-shift errors. BC025275 - Homo sapiens ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H, mRNA (cDNA clone MGC:39180 IMAGE:4646010), complete cds. AF112204 - Homo sapiens Vacuolar proton pump subunit SFD alpha isoform mRNA, complete cds. AF113222 - Homo sapiens MSTP042 mRNA, complete cds. AK094839 - Homo sapiens cDNA FLJ37520 fis, clone BRCAN2005449, highly similar to Sus scrofa mRNA for 54 kDa vacuolar H(+)-ATPase subunit, beta isoform. AK308204 - Homo sapiens cDNA, FLJ98152. AK022345 - Homo sapiens cDNA FLJ12283 fis, clone MAMMA1001754, highly similar to Vacuolar ATP synthase subunit H (EC 3.6.3.14). BC014862 - Homo sapiens cDNA clone IMAGE:3924161, containing frame-shift errors. AK303229 - Homo sapiens cDNA FLJ58444 complete cds, highly similar to Vacuolar ATP synthase subunit H (EC 3.6.3.14). AF298777 - Homo sapiens vacuolar ATPase subunit H mRNA, complete cds. KJ893949 - Synthetic construct Homo sapiens clone ccsbBroadEn_03343 ATP6V1H gene, encodes complete protein. JD250778 - Sequence 231802 from Patent EP1572962. JD073283 - Sequence 54307 from Patent EP1572962. JD021210 - Sequence 2234 from Patent EP1572962. JD025033 - Sequence 6057 from Patent EP1572962. JD026319 - Sequence 7343 from Patent EP1572962. JD027873 - Sequence 8897 from Patent EP1572962. JD027922 - Sequence 8946 from Patent EP1572962. AF125105 - Homo sapiens vacuolar proton pump subunit SFD alpha isoform mRNA, complete cds. JD389982 - Sequence 371006 from Patent EP1572962. JD405789 - Sequence 386813 from Patent EP1572962. JD381638 - Sequence 362662 from Patent EP1572962. JD228462 - Sequence 209486 from Patent EP1572962. JD141791 - Sequence 122815 from Patent EP1572962. DQ572683 - Homo sapiens piRNA piR-40795, complete sequence.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-7980 - ATP biosynthesis
Reactome (by CSHL, EBI, and GO)
Protein Q9UI12 (Reactome details) participates in the following event(s):
R-HSA-167537 Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex R-HSA-182186 Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex R-HSA-167597 Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex R-HSA-182198 Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex R-HSA-5252133 ATP6AP1 binds V-ATPase R-HSA-1222516 Intraphagosomal pH is lowered to 5 by V-ATPase R-HSA-74723 Endosome acidification R-HSA-917841 Acidification of Tf:TfR1 containing endosome R-HSA-167590 Nef Mediated CD4 Down-regulation R-HSA-182218 Nef Mediated CD8 Down-regulation R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-77387 Insulin receptor recycling R-HSA-917977 Transferrin endocytosis and recycling R-HSA-983712 Ion channel transport R-HSA-162909 Host Interactions of HIV factors R-HSA-74752 Signaling by Insulin receptor R-HSA-917937 Iron uptake and transport R-HSA-382551 Transport of small molecules R-HSA-1222556 ROS, RNS production in phagocytes R-HSA-162906 HIV Infection R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-168249 Innate Immune System R-HSA-5663205 Infectious disease R-HSA-162582 Signal Transduction R-HSA-168256 Immune System R-HSA-1643685 Disease
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
