Human Gene DMAC2L (ENST00000245448.11_4) from GENCODE V47lift37
Description: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway. (from UniProt Q99766) Gencode Transcript: ENST00000245448.11_4 Gencode Gene: ENSG00000125375.18_13 Transcript (Including UTRs) Position: hg19 chr14:50,779,047-50,792,944 Size: 13,898 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr14:50,788,206-50,792,349 Size: 4,144 Coding Exon Count: 3
ID:ATP5S_HUMAN DESCRIPTION: RecName: Full=ATP synthase subunit s, mitochondrial; AltName: Full=ATP synthase-coupling factor B; Short=FB; AltName: Full=Mitochondrial ATP synthase regulatory component factor B; Flags: Precursor; FUNCTION: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity). SUBUNIT: Homotetramer. Associates with ATP synthase (By similarity). SUBCELLULAR LOCATION: Mitochondrion (By similarity). Mitochondrion inner membrane (By similarity). SIMILARITY: Belongs to the ATP synthase subunit s family. SIMILARITY: Contains 4 LRR (leucine-rich) repeats. CAUTION: It is uncertain whether Met-1 or Met-16 is the initiator.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99766
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC011549 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B), mRNA (cDNA clone MGC:19945 IMAGE:4554461), complete cds. JD173500 - Sequence 154524 from Patent EP1572962. AF052186 - Homo sapiens clone 24431 mRNA sequence. U79253 - Human clone 23893 mRNA, complete cds. JD467238 - Sequence 448262 from Patent EP1572962. JD459326 - Sequence 440350 from Patent EP1572962. BC087851 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B), mRNA (cDNA clone IMAGE:30399343). JD124746 - Sequence 105770 from Patent EP1572962. JD128753 - Sequence 109777 from Patent EP1572962. JD405737 - Sequence 386761 from Patent EP1572962. AK290008 - Homo sapiens cDNA FLJ77027 complete cds, highly similar to Homo sapiens mitochondrial ATP synthase regulatory component factor B (ATPW) mRNA. JD139909 - Sequence 120933 from Patent EP1572962. JD149838 - Sequence 130862 from Patent EP1572962. JD059194 - Sequence 40218 from Patent EP1572962. JD526547 - Sequence 507571 from Patent EP1572962. AY052377 - Homo sapiens mitochondrial ATP synthase regulatory component factor B (ATPW) mRNA, complete cds; nuclear gene for mitochondrial product. JD040859 - Sequence 21883 from Patent EP1572962. JD552637 - Sequence 533661 from Patent EP1572962. CU679952 - Synthetic construct Homo sapiens gateway clone IMAGE:100018526 5' read ATP5S mRNA. KJ898661 - Synthetic construct Homo sapiens clone ccsbBroadEn_08055 ATP5S gene, encodes complete protein. AF390029 - Homo sapiens ATP synthase coupling factor B-like 1 mRNA, complete cds; nuclear gene for mitochondrial product. JD144716 - Sequence 125740 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q99766 (Reactome details) participates in the following event(s):
R-HSA-164840 ADP and Pi bind to ATPase R-HSA-8949580 F1Fo ATP synthase dimerizes R-HSA-164834 Enzyme-bound ATP is released R-HSA-164832 ATPase synthesizes ATP R-HSA-163210 Formation of ATP by chemiosmotic coupling R-HSA-8949613 Cristae formation R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1592230 Mitochondrial biogenesis R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
