Human Gene ARL2 (ENST00000246747.9_4) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: ADP ribosylation factor like GTPase 2, transcript variant 1 (from RefSeq NM_001667.4)
Gencode Transcript: ENST00000246747.9_4
Gencode Gene: ENSG00000213465.8_8
Transcript (Including UTRs)
Position: hg19 chr11:64,781,632-64,789,656 Size: 8,025 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr11:64,781,680-64,789,327 Size: 7,648 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:64,781,632-64,789,656)			mRNA (may differ from genome)		Protein (184 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Q53YD8_HUMAN DESCRIPTION: SubName: Full=ADP-ribosylation factor-like 2; SubName: Full=ADP-ribosylation factor-like 2 variant; SubName: Full=HCG23373, isoform CRA_a; SIMILARITY: Belongs to the small GTPase superfamily. Arf family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ARL2 Diseases sorted by gene-association score: deafness, autosomal recessive 88 (5), retinitis pigmentosa 66 (3), hypoparathyroidism-retardation-dysmorphism syndrome (2), retinitis pigmentosa (1), joubert syndrome 1 (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003993 Dibutyl Phthalate D000643 Ammonium Chloride D001104 Arbutin C099555 CD 437 D002794 Choline D019327 Copper Sulfate D004997 Ethinyl Estradiol D005492 Folic Acid D006830 Hydralazine D006997 Hypochlorous Acid more ... click here to view the complete list

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 175.87 RPKM in Brain - Nucleus accumbens (basal ganglia) Total median expression: 4319.74 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-18.50	48	-0.385	Picture	PostScript	Text
3' UTR	-120.80	329	-0.367	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR024156 - Small_GTPase_ARF
IPR006689 - Small_GTPase_ARF/SAR

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF01926 - 50S ribosome-binding GTPase
PF04670 - Gtr1/RagA G protein conserved region
PF08477 - Ras of Complex, Roc, domain of DAPkinase
PF09439 - Signal recognition particle receptor beta subunit

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q53YD8


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0005525 GTP binding Cellular Component: GO:0005622 intracellular GO:0005634 nucleus GO:0005730 nucleolus GO:0005794 Golgi apparatus GO:0005829 cytosol GO:0005925 focal adhesion

Descriptions from all associated GenBank mRNAs


	AK223502 - Homo sapiens mRNA for ADP-ribosylation factor-like 2 variant, clone: FCC121D06. BC002530 - Homo sapiens ADP-ribosylation factor-like 2, mRNA (cDNA clone MGC:1800 IMAGE:3140402), complete cds. AK096447 - Homo sapiens cDNA FLJ39128 fis, clone NTONG2007658, highly similar to Sorting nexin-15. L13687 - Homo sapiens ADP-ribosylation factor-like protein 2 (ARL2) mRNA, complete cds. JD215061 - Sequence 196085 from Patent EP1572962. EU832671 - Synthetic construct Homo sapiens clone HAIB:100067700; DKFZo008H0431 ADP-ribosylation factor-like 2 protein (ARL2) gene, encodes complete protein. EU832750 - Synthetic construct Homo sapiens clone HAIB:100067779; DKFZo004H0432 ADP-ribosylation factor-like 2 protein (ARL2) gene, encodes complete protein. AB527923 - Synthetic construct DNA, clone: pF1KB0953, Homo sapiens ARL2 gene for ADP-ribosylation factor-like 2, without stop codon, in Flexi system. AK294580 - Homo sapiens cDNA FLJ58989 complete cds, moderately similar to ADP-ribosylation factor-like protein 2. KJ890710 - Synthetic construct Homo sapiens clone ccsbBroadEn_00104 ARL2 gene, encodes complete protein. BT006674 - Homo sapiens ADP-ribosylation factor-like 2 mRNA, complete cds. AF493888 - Homo sapiens ADP-ribosylation factor-like protein 2 (ARL2) mRNA, complete cds. JD042960 - Sequence 23984 from Patent EP1572962. JD320245 - Sequence 301269 from Patent EP1572962. JD339071 - Sequence 320095 from Patent EP1572962. JD286960 - Sequence 267984 from Patent EP1572962. JD220490 - Sequence 201514 from Patent EP1572962. JD383670 - Sequence 364694 from Patent EP1572962. JD126644 - Sequence 107668 from Patent EP1572962. JD058604 - Sequence 39628 from Patent EP1572962. JD253326 - Sequence 234350 from Patent EP1572962. JD389484 - Sequence 370508 from Patent EP1572962. JD272645 - Sequence 253669 from Patent EP1572962. JD423415 - Sequence 404439 from Patent EP1572962. JD458779 - Sequence 439803 from Patent EP1572962. JD198544 - Sequence 179568 from Patent EP1572962. JD175293 - Sequence 156317 from Patent EP1572962. JD066115 - Sequence 47139 from Patent EP1572962. JD339939 - Sequence 320963 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000246747.1, ENST00000246747.2, ENST00000246747.3, ENST00000246747.4, ENST00000246747.5, ENST00000246747.6, ENST00000246747.7, ENST00000246747.8, hCG_23373 , NM_001667, Q53YD8, Q53YD8_HUMAN, uc317euc.1, uc317euc.2 UCSC ID: ENST00000246747.9_4 RefSeq Accession: NM_001667.4 Protein: Q53YD8

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.