ID:DP13A_HUMAN DESCRIPTION: RecName: Full=DCC-interacting protein 13-alpha; Short=Dip13-alpha; AltName: Full=Adapter protein containing PH domain, PTB domain and leucine zipper motif 1; FUNCTION: Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. SUBUNIT: Binds RAB5A/Rab5 through an N-terminal domain. This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex. Interacts with OCRL and INPP5B. INTERACTION: P35609:ACTN2; NbExp=2; IntAct=EBI-741243, EBI-77797; Q96A54:ADIPOR1; NbExp=6; IntAct=EBI-741243, EBI-1632076; Q91VH1:Adipor1 (xeno); NbExp=3; IntAct=EBI-741243, EBI-992398; Q86V24:ADIPOR2; NbExp=3; IntAct=EBI-741243, EBI-1769445; Q03001:DST; NbExp=3; IntAct=EBI-741243, EBI-310758; O75923:DYSF; NbExp=2; IntAct=EBI-741243, EBI-2799016; Q8WXH0:SYNE2; NbExp=3; IntAct=EBI-741243, EBI-2372294; SUBCELLULAR LOCATION: Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. TISSUE SPECIFICITY: High levels in heart, ovary, pancreas and skeletal muscle. DOMAIN: Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect. DOMAIN: The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B (PubMed:21666675). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Phosophorylation at Ser-410 by PKA severely impairs binding to OCRL. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 PID domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UKG1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
