Human Gene ANKZF1 (ENST00000323348.10_4) from GENCODE V47lift37

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Description: ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1, transcript variant 1 (from RefSeq NM_018089.3)
Gencode Transcript: ENST00000323348.10_4
Gencode Gene: ENSG00000163516.14_10
Transcript (Including UTRs)
Position: hg19 chr2:220,094,528-220,101,401 Size: 6,874 Total Exon Count: 14 Strand: +
Coding Region
Position: hg19 chr2:220,094,980-220,101,167 Size: 6,188 Coding Exon Count: 13

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:220,094,528-220,101,401)			mRNA (may differ from genome)		Protein (726 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ANKZ1_HUMAN DESCRIPTION: RecName: Full=Ankyrin repeat and zinc finger domain-containing protein 1; AltName: Full=Zinc finger protein 744; FUNCTION: Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity). INTERACTION: Q9Q2G4:ORF (xeno); NbExp=2; IntAct=EBI-724848, EBI-6248094; SIMILARITY: Belongs to the ANKZF1/VMS1 family. SIMILARITY: Contains 2 ANK repeats. SIMILARITY: Contains 1 C2H2-type zinc finger. SEQUENCE CAUTION: Sequence=ABD65410.1; Type=Frameshift; Positions=318; Sequence=BAA91596.1; Type=Frameshift; Positions=318;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl D000082 Acetaminophen D001564 Benzo(a)pyrene D002251 Carbon Tetrachloride D019327 Copper Sulfate D003474 Curcumin D018817 N-Methyl-3,4-methylenedioxyamphetamine C018021 cobaltous chloride more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 50.77 RPKM in Brain - Cerebellum Total median expression: 975.89 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-41.20	125	-0.330	Picture	PostScript	Text
3' UTR	-74.40	234	-0.318	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like

Pfam Domains:
PF00023 - Ankyrin repeat
PF13606 - Ankyrin repeat
PF18716 - Vms1-associating treble clef domain
PF18826 - Bacteroidetes VLRF1 release factor

SCOP Domains:
140860 - Pseudo ankyrin repeat-like
48403 - Ankyrin repeat
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on Q9H8Y5


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003676 nucleic acid binding GO:0005515 protein binding GO:0046872 metal ion binding GO:0004843 thiol-dependent ubiquitin-specific protease activity Biological Process: GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0070301 cellular response to hydrogen peroxide GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process Cellular Component: GO:0005737 cytoplasm GO:0016020 membrane GO:0036266 Cdc48p-Npl4p-Vms1p AAA ATPase complex

Descriptions from all associated GenBank mRNAs


	LF205250 - JP 2014500723-A/12753: Polycomb-Associated Non-Coding RNAs. AK001277 - Homo sapiens cDNA FLJ10415 fis, clone NT2RP1000101. DQ412564 - Homo sapiens ankyrin repeat and zinc finger domain containing 1 (ANKZF1) mRNA, complete cds. AK225275 - Homo sapiens mRNA for Hypothetical protein FLJ13144 variant, clone: HEP00623. BC028334 - Homo sapiens ankyrin repeat and zinc finger domain containing 1, mRNA (cDNA clone IMAGE:4510516). AK303537 - Homo sapiens cDNA FLJ58218 complete cds, highly similar to Ankyrin repeat and zinc fingerdomain-containing protein 1. AK095304 - Homo sapiens cDNA FLJ37985 fis, clone CTONG2010821. BC008948 - Homo sapiens ankyrin repeat and zinc finger domain containing 1, mRNA (cDNA clone MGC:3426 IMAGE:2959748), complete cds. AF364318 - Homo sapiens RAMA2-like protein mRNA, complete sequence. AK303077 - Homo sapiens cDNA FLJ57244 complete cds, highly similar to Ankyrin repeat and zinc fingerdomain-containing protein 1. AK225309 - Homo sapiens mRNA for Hypothetical protein FLJ13144 variant, clone: HEP05434. BC000238 - Homo sapiens ankyrin repeat and zinc finger domain containing 1, mRNA (cDNA clone MGC:969 IMAGE:3351742), complete cds. JD514531 - Sequence 495555 from Patent EP1572962. AK023206 - Homo sapiens cDNA FLJ13144 fis, clone NT2RP3003278. KJ894138 - Synthetic construct Homo sapiens clone ccsbBroadEn_03532 ANKZF1 gene, encodes complete protein. AK098282 - Homo sapiens cDNA FLJ40963 fis, clone UTERU2011906. JD026596 - Sequence 7620 from Patent EP1572962. JD029831 - Sequence 10855 from Patent EP1572962. JD112725 - Sequence 93749 from Patent EP1572962. JD062200 - Sequence 43224 from Patent EP1572962. JD435916 - Sequence 416940 from Patent EP1572962. AK056060 - Homo sapiens cDNA FLJ31498 fis, clone NT2NE2005371. JD220939 - Sequence 201963 from Patent EP1572962. JD270280 - Sequence 251304 from Patent EP1572962. JD120964 - Sequence 101988 from Patent EP1572962. JD380763 - Sequence 361787 from Patent EP1572962. JD462280 - Sequence 443304 from Patent EP1572962. JD141671 - Sequence 122695 from Patent EP1572962. JD302227 - Sequence 283251 from Patent EP1572962. JD487132 - Sequence 468156 from Patent EP1572962. JD410295 - Sequence 391319 from Patent EP1572962. JD238763 - Sequence 219787 from Patent EP1572962. JD372707 - Sequence 353731 from Patent EP1572962. JD444974 - Sequence 425998 from Patent EP1572962. JD168753 - Sequence 149777 from Patent EP1572962. JD068226 - Sequence 49250 from Patent EP1572962. JD068118 - Sequence 49142 from Patent EP1572962. JD474597 - Sequence 455621 from Patent EP1572962. JD080798 - Sequence 61822 from Patent EP1572962. JD442368 - Sequence 423392 from Patent EP1572962. JD058890 - Sequence 39914 from Patent EP1572962. JD494814 - Sequence 475838 from Patent EP1572962. JD064451 - Sequence 45475 from Patent EP1572962. MA440827 - JP 2018138019-A/12753: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: ANKZ1_HUMAN, ANKZF1 , ENST00000323348.1, ENST00000323348.2, ENST00000323348.3, ENST00000323348.4, ENST00000323348.5, ENST00000323348.6, ENST00000323348.7, ENST00000323348.8, ENST00000323348.9, NM_018089, Q9H8Y5, Q9NVZ4, uc317rli.1, uc317rli.2, ZNF744 UCSC ID: ENST00000323348.10_4 RefSeq Accession: NM_018089.3 Protein: Q9H8Y5 (aka ANKZ1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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