Human Gene ANKRD35 (ENST00000355594.9_4) from GENCODE V47lift37

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Description: ankyrin repeat domain 35, transcript variant 1 (from RefSeq NM_144698.5)
Gencode Transcript: ENST00000355594.9_4
Gencode Gene: ENSG00000198483.13_7
Transcript (Including UTRs)
Position: hg19 chr1:145,549,209-145,568,522 Size: 19,314 Total Exon Count: 14 Strand: +
Coding Region
Position: hg19 chr1:145,549,317-145,567,756 Size: 18,440 Coding Exon Count: 13

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:145,549,209-145,568,522)			mRNA (may differ from genome)		Protein (1001 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ANR35_HUMAN DESCRIPTION: RecName: Full=Ankyrin repeat domain-containing protein 35; SIMILARITY: Contains 6 ANK repeats. SEQUENCE CAUTION: Sequence=BAB71597.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003993 Dibutyl Phthalate C006253 pirinixic acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 45.53 RPKM in Skin - Sun Exposed (Lower leg) Total median expression: 285.97 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-32.90	108	-0.305	Picture	PostScript	Text
3' UTR	-77.10	245	-0.315	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom

Pfam Domains:
PF00023 - Ankyrin repeat
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)

SCOP Domains:
140860 - Pseudo ankyrin repeat-like
101447 - Formin homology 2 domain (FH2 domain)
48403 - Ankyrin repeat
58104 - Methyl-accepting chemotaxis protein (MCP) signaling domain

ModBase Predicted Comparative 3D Structure on Q8N283


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	AK294308 - Homo sapiens cDNA FLJ58791 complete cds, highly similar to Ankyrin repeat domain-containing protein 35. AK296861 - Homo sapiens cDNA FLJ57392 complete cds, highly similar to Ankyrin repeat domain-containing protein 35. AK091120 - Homo sapiens cDNA FLJ33801 fis, clone CTONG2000411. AX746788 - Sequence 313 from Patent EP1308459. BC101618 - Homo sapiens ankyrin repeat domain 35, mRNA (cDNA clone MGC:126667 IMAGE:8069124), complete cds. BC101620 - Homo sapiens ankyrin repeat domain 35, mRNA (cDNA clone MGC:126669 IMAGE:8069126), complete cds. AK057853 - Homo sapiens cDNA FLJ25124 fis, clone CBR06414. JD283890 - Sequence 264914 from Patent EP1572962. JD445304 - Sequence 426328 from Patent EP1572962. JD213591 - Sequence 194615 from Patent EP1572962. JD131634 - Sequence 112658 from Patent EP1572962. JD055795 - Sequence 36819 from Patent EP1572962. JD449076 - Sequence 430100 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A6NEU0, ANR35_HUMAN, B4DL62, ENST00000355594.1, ENST00000355594.2, ENST00000355594.3, ENST00000355594.4, ENST00000355594.5, ENST00000355594.6, ENST00000355594.7, ENST00000355594.8, NM_144698, Q3MJ10, Q8N283, Q96LS3, uc317zdr.1, uc317zdr.2 UCSC ID: ENST00000355594.9_4 RefSeq Accession: NM_144698.5 Protein: Q8N283 (aka ANR35_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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