ID:ANGP1_HUMAN DESCRIPTION: RecName: Full=Angiopoietin-1; Short=ANG-1; Flags: Precursor; FUNCTION: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. SUBUNIT: Homooligomer. Interacts with TEK/TIE2. SUBCELLULAR LOCATION: Secreted. PTM: Glycosylated. MISCELLANEOUS: It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart. SIMILARITY: Contains 1 fibrinogen C-terminal domain. SEQUENCE CAUTION: Sequence=BAA02793.2; Type=Erroneous initiation; WEB RESOURCE: Name=Wikipedia; Note=Angiopoietin entry; URL="http://en.wikipedia.org/wiki/Angiopoietin";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15389
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0001525 angiogenesis GO:0001701 in utero embryonic development GO:0001933 negative regulation of protein phosphorylation GO:0002040 sprouting angiogenesis GO:0002092 positive regulation of receptor internalization GO:0002740 negative regulation of cytokine secretion involved in immune response GO:0007162 negative regulation of cell adhesion GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity GO:0007275 multicellular organism development GO:0010595 positive regulation of endothelial cell migration GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014842 regulation of skeletal muscle satellite cell proliferation GO:0030097 hemopoiesis GO:0030154 cell differentiation GO:0030210 heparin biosynthetic process GO:0031398 positive regulation of protein ubiquitination GO:0031589 cell-substrate adhesion GO:0032680 regulation of tumor necrosis factor production GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0034394 protein localization to cell surface GO:0042308 negative regulation of protein import into nucleus GO:0043066 negative regulation of apoptotic process GO:0043116 negative regulation of vascular permeability GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043393 regulation of protein binding GO:0043524 negative regulation of neuron apoptotic process GO:0043536 positive regulation of blood vessel endothelial cell migration GO:0045785 positive regulation of cell adhesion GO:0048014 Tie signaling pathway GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050900 leukocyte migration GO:0050918 positive chemotaxis GO:0051897 positive regulation of protein kinase B signaling GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0072012 glomerulus vasculature development GO:2000352 negative regulation of endothelial cell apoptotic process GO:2000446 regulation of macrophage migration inhibitory factor signaling pathway GO:0001936 regulation of endothelial cell proliferation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
