Human Gene AMMECR1L (ENST00000272647.10

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Human Gene AMMECR1L (ENST00000272647.10_7) from GENCODE V47lift37

Description: AMMECR1 like, transcript variant 2 (from RefSeq NM_001199140.2)
Gencode Transcript: ENST00000272647.10_7
Gencode Gene: ENSG00000144233.12_11
Transcript (Including UTRs)
Position: hg19 chr2:128,619,204-128,643,530 Size: 24,327 Total Exon Count: 8 Strand: -
Coding Region
Position: hg19 chr2:128,622,668-128,631,808 Size: 9,141 Coding Exon Count: 6

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	mRNA Descriptions	Other Names
Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:128,619,204-128,643,530)			mRNA (may differ from genome)		Protein (310 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: AMERL_HUMAN DESCRIPTION: RecName: Full=AMMECR1-like protein; SIMILARITY: Contains 1 AMMECR1 domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D010634 Phenobarbital D013749 Tetrachlorodibenzodioxin C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) D000082 Acetaminophen D000086 Acetazolamide D016604 Aflatoxin B1 D019327 Copper Sulfate D016572 Cyclosporine D003993 Dibutyl Phthalate D004997 Ethinyl Estradiol more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 14.64 RPKM in Testis Total median expression: 365.85 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-93.60	295	-0.317	Picture	PostScript	Text
3' UTR	-1100.60	3464	-0.318	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR023473 - AMMECR1
IPR002733 - AMMECR1_domain

Pfam Domains:
PF01871 - AMMECR1

SCOP Domains:
143447 - AMMECR1-like

ModBase Predicted Comparative 3D Structure on Q6DCA0


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	AL137415 - Homo sapiens mRNA; cDNA DKFZp434O172 (from clone DKFZp434O172). BC084552 - Homo sapiens cDNA clone IMAGE:6212324. BC004208 - Homo sapiens hypothetical protein MGC4268, mRNA (cDNA clone IMAGE:3532352), partial cds. AK024993 - Homo sapiens cDNA: FLJ21340 fis, clone COL02623. BC016181 - Homo sapiens AMME chromosomal region gene 1-like, mRNA (cDNA clone MGC:20482 IMAGE:4644159), complete cds. BC078174 - Homo sapiens AMME chromosomal region gene 1-like, mRNA (cDNA clone MGC:88063 IMAGE:6012672), complete cds. LF385240 - JP 2014500723-A/192743: Polycomb-Associated Non-Coding RNAs. JD301209 - Sequence 282233 from Patent EP1572962. JD235344 - Sequence 216368 from Patent EP1572962. BC067124 - Homo sapiens cDNA clone IMAGE:6159192, partial cds. AK026685 - Homo sapiens cDNA: FLJ23032 fis, clone LNG01938. JD313447 - Sequence 294471 from Patent EP1572962. JD488338 - Sequence 469362 from Patent EP1572962. JD146005 - Sequence 127029 from Patent EP1572962. JD130686 - Sequence 111710 from Patent EP1572962. JD242468 - Sequence 223492 from Patent EP1572962. JD060323 - Sequence 41347 from Patent EP1572962. JD112848 - Sequence 93872 from Patent EP1572962. LF342912 - JP 2014500723-A/150415: Polycomb-Associated Non-Coding RNAs. JD234270 - Sequence 215294 from Patent EP1572962. JD140384 - Sequence 121408 from Patent EP1572962. AK095871 - Homo sapiens cDNA FLJ38552 fis, clone HCHON2002241. LF342911 - JP 2014500723-A/150414: Polycomb-Associated Non-Coding RNAs. DQ600924 - Homo sapiens piRNA piR-38990, complete sequence. LF342910 - JP 2014500723-A/150413: Polycomb-Associated Non-Coding RNAs. LF342909 - JP 2014500723-A/150412: Polycomb-Associated Non-Coding RNAs. LF383489 - JP 2014500723-A/190992: Polycomb-Associated Non-Coding RNAs. AK304145 - Homo sapiens cDNA FLJ52670 complete cds, moderately similar to AMME syndrome candidate gene 1 protein. HQ447546 - Synthetic construct Homo sapiens clone IMAGE:100070885; CCSB014666_01 AMME chromosomal region gene 1-like (AMMECR1L) gene, encodes complete protein. KJ894888 - Synthetic construct Homo sapiens clone ccsbBroadEn_04282 AMMECR1L gene, encodes complete protein. CU687324 - Synthetic construct Homo sapiens gateway clone IMAGE:100022907 5' read AMMECR1L mRNA. MA620817 - JP 2018138019-A/192743: Polycomb-Associated Non-Coding RNAs. MA578489 - JP 2018138019-A/150415: Polycomb-Associated Non-Coding RNAs. MA578488 - JP 2018138019-A/150414: Polycomb-Associated Non-Coding RNAs. MA578487 - JP 2018138019-A/150413: Polycomb-Associated Non-Coding RNAs. MA578486 - JP 2018138019-A/150412: Polycomb-Associated Non-Coding RNAs. MA619066 - JP 2018138019-A/190992: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: AMERL_HUMAN, B4E276, ENST00000272647.1, ENST00000272647.2, ENST00000272647.3, ENST00000272647.4, ENST00000272647.5, ENST00000272647.6, ENST00000272647.7, ENST00000272647.8, ENST00000272647.9, NM_001199140, Q6DCA0, uc317izq.1, uc317izq.2 UCSC ID: ENST00000272647.10_7 RefSeq Accession: NM_001199140.2 Protein: Q6DCA0 (aka AMERL_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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