Human Gene AKR7A3 (ENST00000361640.5_7) from GENCODE V47lift37

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Description: aldo-keto reductase family 7 member A3 (from RefSeq NM_012067.3)
Gencode Transcript: ENST00000361640.5_7
Gencode Gene: ENSG00000162482.5_9
Transcript (Including UTRs)
Position: hg19 chr1:19,609,067-19,615,264 Size: 6,198 Total Exon Count: 7 Strand: -
Coding Region
Position: hg19 chr1:19,609,225-19,615,203 Size: 5,979 Coding Exon Count: 7

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:19,609,067-19,615,264)			mRNA (may differ from genome)		Protein (331 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ARK73_HUMAN DESCRIPTION: RecName: Full=Aflatoxin B1 aldehyde reductase member 3; EC=1.-.-.-; AltName: Full=AFB1 aldehyde reductase 2; Short=AFB1-AR 2; FUNCTION: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium. SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.

Primer design for this transcript

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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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MalaCards Disease Associations


	MalaCards Gene Search: AKR7A3 Diseases sorted by gene-association score: pancreas adenocarcinoma (6)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C005399 9,10-phenanthrenequinone D016604 Aflatoxin B1 C492600 (2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate C012277 1,2-diamino-4-nitrobenzene C049325 1,2-dithiol-3-thione C576882 1-(2-trifluoromethoxyphenyl)-2-nitroethanone C035314 1-nitropropane C029141 2,2,5,7,8-pentamethyl-1-hydroxychroman C010914 2,4-diaminotoluene C016403 2,4-dinitrotoluene C025235 2,6-diaminotoluene C023514 2,6-dinitrotoluene D015073 2-Acetylaminofluorene C035208 2-amino-4,6-dinitrotoluene C014706 2-nitro-4-phenylenediamine C019499 2-nitrofluorene C016617 2-nitropropane C023035 3,4,5,3',4'-pentachlorobiphenyl C017906 3-dinitrobenzene C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone C028676 4-acetylaminofluorene C035207 4-amino-2,6-dinitrotoluene C117714 4-hydroxyequilenin-o-quinone C522589 5,6-dihydrocyclopenta-1,2-dithiole-3-thione D000082 Acetaminophen D000171 Acrolein D000638 Amiodarone D000643 Ammonium Chloride D001553 Benzbromarone D001554 Benzene D001564 Benzo(a)pyrene D002083 Butylated Hydroxyanisole D002084 Butylated Hydroxytoluene D002211 Capsaicin D002220 Carbamazepine D020111 Chlorodiphenyl (54% Chlorine) D002725 Chloroform D002911 Chrysenes D002945 Cisplatin D002994 Clofibrate D003042 Cocaine D019327 Copper Sulfate D016572 Cyclosporine D003993 Dibutyl Phthalate D004006 Dichlorvos D004041 Dietary Fats D004052 Diethylnitrosamine D004101 Dihydroxydihydrobenzopyrenes D004128 Dimethylnitrosamine D000431 Ethanol D004997 Ethinyl Estradiol D005001 Ethionine D005015 Ethoxyquin D015725 Fluconazole D015248 Gemfibrozil D005839 Gentamicins D005978 Glutathione D001556 Lindane D008550 Melatonin D008701 Methapyrilene C002741 N-nitrosomorpholine D009249 NADP D009281 Naphthalenes D009853 Omeprazole D010634 Phenobarbital D010672 Phenytoin D010882 Piperonyl Butoxide D011223 Praziquantel D011285 Pregnenolone Carbonitrile D011441 Propylthiouracil D011794 Quercetin D013749 Tetrachlorodibenzodioxin D013853 Thioacetamide D014050 Toluene D014241 Trichloroethylene D014303 Trinitrotoluene D014315 Triterpenes D014635 Valproic Acid C098408 aflatoxin-albumin adduct C038491 allyl sulfide C030233 benzo(a)pyrene-1,6-quinone C076588 benzo(a)pyrene-7,8-dione D019324 beta-Naphthoflavone C002791 bismuth tripotassium dicitrate C032036 bromobenzene C053400 cafestol C030123 coumarin C076840 ethofenprox C047360 felbamate C039281 furan C040029 gabapentin C020758 indium trichloride C016517 indole-3-carbinol C016527 isoquercitrin C053401 kahweol C008261 lead acetate C014707 nitrosobenzylmethylamine C025589 ochratoxin A C026209 oltipraz C011030 oxfendazole C076994 perfluorooctane sulfonic acid C058305 phenethyl isothiocyanate C006253 pirinixic acid C045950 propiconazole C010330 sinigrin C009338 succinic semialdehyde C032910 triadimefon

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 149.54 RPKM in Stomach Total median expression: 510.22 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-21.10	61	-0.346	Picture	PostScript	Text
3' UTR	-28.00	158	-0.177	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001395 - Aldo/ket_red
IPR023210 - NADP_OxRdtase_dom

Pfam Domains:
PF00248 - Aldo/keto reductase family

SCOP Domains:
51430 - NAD(P)-linked oxidoreductase

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2CLP - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on O95154


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser
Gene Details	Gene Details				Gene Details
Gene Sorter	Gene Sorter				Gene Sorter
	RGD				SGD
					Protein Sequence
					Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004033 aldo-keto reductase (NADP) activity GO:0005515 protein binding GO:0009055 electron carrier activity GO:0016491 oxidoreductase activity GO:0042802 identical protein binding Biological Process: GO:0006081 cellular aldehyde metabolic process GO:0006805 xenobiotic metabolic process GO:0022900 electron transport chain GO:0055114 oxidation-reduction process Cellular Component: GO:0005737 cytoplasm GO:0005829 cytosol GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	KJ898428 - Synthetic construct Homo sapiens clone ccsbBroadEn_07822 AKR7A3 gene, encodes complete protein. KR710653 - Synthetic construct Homo sapiens clone CCSBHm_00015213 AKR7A3 (AKR7A3) mRNA, encodes complete protein. BC042420 - Homo sapiens aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase), mRNA (cDNA clone MGC:34818 IMAGE:5186889), complete cds. GQ891370 - Homo sapiens clone HEL-S-158l epididymis secretory sperm binding protein mRNA, complete cds. AJ271799 - Homo sapiens mRNA for aflatoxin B1 aldehyde reductase 2 (AFAR2 gene). BC025709 - Homo sapiens aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase), mRNA (cDNA clone MGC:34394 IMAGE:5224626), complete cds. AF040639 - Homo sapiens aflatoxin B1-aldehyde reductase mRNA, complete cds. BC031562 - Homo sapiens aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase), mRNA (cDNA clone MGC:34393 IMAGE:5184829), complete cds. JD308653 - Sequence 289677 from Patent EP1572962. JD165059 - Sequence 146083 from Patent EP1572962. JD289913 - Sequence 270937 from Patent EP1572962. JD352138 - Sequence 333162 from Patent EP1572962. EU176235 - Synthetic construct Homo sapiens clone IMAGE:100006584; FLH263911.01X; RZPDo839B05246D aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) (AKR7A3) gene, encodes complete protein. EU176541 - Synthetic construct Homo sapiens clone IMAGE:100011358; FLH167825.01L; RZPDo839E08253D aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) (AKR7A3) gene, encodes complete protein. GQ891371 - Homo sapiens clone HEL-S-159l epididymis secretory sperm binding protein mRNA, complete cds. KJ898429 - Synthetic construct Homo sapiens clone ccsbBroadEn_07823 AKR7A3 gene, encodes complete protein. EU831806 - Synthetic construct Homo sapiens clone HAIB:100066835; DKFZo008F0221 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) protein (AKR7A3) gene, encodes complete protein. EU831883 - Synthetic construct Homo sapiens clone HAIB:100066912; DKFZo004F0222 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) protein (AKR7A3) gene, encodes complete protein. CU693022 - Synthetic construct Homo sapiens gateway clone IMAGE:100016720 5' read AKR7A3 mRNA. JD555212 - Sequence 536236 from Patent EP1572962. JD394388 - Sequence 375412 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein O95154 (Reactome details) participates in the following event(s): R-HSA-5423637 AKR dimers reduce AFBDHO to AFBDOH R-HSA-5423646 Aflatoxin activation and detoxification R-HSA-211859 Biological oxidations R-HSA-1430728 Metabolism

Other Names for This Gene


	Alternate Gene Symbols: AFAR2, ARK73_HUMAN, ENST00000361640.1, ENST00000361640.2, ENST00000361640.3, ENST00000361640.4, NM_012067, O95154, Q86SR4, Q8IVN6, Q8N5V6, Q8TAX1, Q9NUC3, uc318cfk.1, uc318cfk.2 UCSC ID: ENST00000361640.5_7 RefSeq Accession: NM_012067.3 Protein: O95154 (aka ARK73_HUMAN or AR73_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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